000111686 001__ 111686
000111686 005__ 20230519145609.0
000111686 0247_ $$2doi$$a10.1159/000515180
000111686 0248_ $$2sideral$$a127873
000111686 037__ $$aART-2021-127873
000111686 041__ $$aeng
000111686 100__ $$aSemenzato, U.
000111686 245__ $$aLow-blood lymphocyte number and lymphocyte decline as key factors in COPD outcomes: a longitudinal cohort study
000111686 260__ $$c2021
000111686 5060_ $$aAccess copy available to the general public$$fUnrestricted
000111686 5203_ $$aBackground: Smokers with and without chronic obstructive pulmonary disease (COPD) are at risk of severe outcomes like exacerbations, cancer, respiratory failure, and decreased survival. The mechanisms for these outcomes are unclear; however, there is evidence that blood lymphocytes (BL) number might play a role. Objective: The objective of this study is to investigate the relationship between BL and their possible decline over time with long-term outcomes in smokers with and without COPD. Methods: In 511 smokers, 302 with COPD (COPD) and 209 without COPD (noCOPD), followed long term, we investigated whether BL number and BL decline over time might be associated with long-term outcomes. Smokers were divided according to BL number in high-BL (=1, 800 cells/µL) and low-BL (<1, 800 cells/µL). Clinical features, cancer incidence, and mortality were recorded during follow-up. BL count in multiple samples and BL decline over time were calculated and related to outcomes. Results: BL count was lower in COPD (1, 880 cells/µL) than noCOPD (2, 300 cells/µL; p < 0.001). 43% of COPD and 23% of noCOPD had low-BL count (p < 0.001). BL decline over time was higher in COPD than noCOPD (p = 0.040). 22.5% of the whole cohort developed cancer which incidence was higher in low-BL subjects and in BL decliners than high-BL (31 vs. 18%; p = 0.001) and no decliners (32 vs. 19%; p = 0.002). 26% in the cohort died during follow-up. Furthermore, low-BL count, BL decline, and age were independent risk factors for mortality by Cox regression analysis. Conclusion: BL count and BL decline are related to worse outcomes in smokers with and without COPD, which suggests that BL count and decline might play a mechanistic role in outcomes deterioration. Insights into mechanisms inducing the fall in BL count could improve the understanding of COPD pathogenesis and point toward new therapeutic measures.
000111686 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000111686 590__ $$a3.966$$b2021
000111686 592__ $$a1.084$$b2021
000111686 594__ $$a6.4$$b2021
000111686 591__ $$aRESPIRATORY SYSTEM$$b31 / 66 = 0.47$$c2021$$dQ2$$eT2
000111686 593__ $$aPulmonary and Respiratory Medicine$$c2021$$dQ1
000111686 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000111686 700__ $$aBiondini, D.
000111686 700__ $$aBazzan, E.
000111686 700__ $$aTiné, M.
000111686 700__ $$aBalestro, E.
000111686 700__ $$aBuldini, B.
000111686 700__ $$aCarizzo, S. J.
000111686 700__ $$aCubero, P.
000111686 700__ $$aMarin-Oto, M.
000111686 700__ $$aCasara, A.
000111686 700__ $$aBaraldo, S.
000111686 700__ $$aTurato, G.
000111686 700__ $$aGregori, D.
000111686 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, J. M.$$uUniversidad de Zaragoza
000111686 700__ $$aCosio, M. G.
000111686 700__ $$aSaetta, M.
000111686 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000111686 773__ $$g100, 7 (2021), 618-630$$pRespiration$$tRESPIRATION$$x0025-7931
000111686 8564_ $$s554803$$uhttps://zaguan.unizar.es/record/111686/files/texto_completo.pdf$$yVersión publicada
000111686 8564_ $$s2258178$$uhttps://zaguan.unizar.es/record/111686/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000111686 909CO $$ooai:zaguan.unizar.es:111686$$particulos$$pdriver
000111686 951__ $$a2023-05-18-16:06:51
000111686 980__ $$aARTICLE