111692 20240319080959.0 doi 10.3390/cells11030392 sideral 127813 ART-2022-127813 eng Reina-Ortiz, Chantal Harnessing the potential of NK cell-based immunotherapies against multiple myeloma 2022 Access copy available to the general public Unrestricted Natural killer (NK) cell-based therapies have emerged as promising anticancer treatments due to their potency as cytolytic effectors and synergy with concurrent treatments. Multiple myeloma (MM) is an aggressive B-cell malignancy that, despite development of novel therapeutic agents, remains incurable with a high rate of relapse. In MM, the inhospitable tumor microenvironment prevents host NK cells from exerting their cytolytic function. The development of NK cell immunotherapy works to overcome this altered immune landscape and can be classified in two major groups based on the origin of the cell: autologous or allogeneic. In this review, we compare the treatments in each group, such as autologous chimeric antigen receptor (CAR) NKs and allogeneic off-the-shelf NK cell infusions, and their combinatorial effect with existing MM therapies including monoclonal antibodies and proteasome inhibitors. We also discuss their placement in clinical treatment regimens based on the immune profile of each patient. Through this examination, we would like to discover precisely when each NK cell-based treatment will produce the maximum benefit to the MM patient. info:eu-repo/grantAgreement/ES/DGA/B31-20R info:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033 info:eu-repo/grantAgreement/ES/MICINN/PID2019-105128RB-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.0 2022 CELL BIOLOGY 60 / 191 = 0.314 2022 Q2 T1 1.537 2022 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2022 Q1 9.0 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Giraldos, David Azaceta, Gemma Palomera, Luis Marzo, Isabel Universidad de Zaragoza (orcid)0000-0002-2315-9079 Naval, Javier Villalba, Martín Anel, Alberto 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 11, 3 (2022), 392 [17 pp.] Cells Cells 2073-4409 852557 http://zaguan.unizar.es/record/111692/files/texto_completo.pdf Versión publicada 2655210 http://zaguan.unizar.es/record/111692/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:111692 articulos driver 2024-03-18-13:55:45 ARTICLE