000111705 001__ 111705
000111705 005__ 20240319081000.0
000111705 0247_ $$2doi$$a10.3390/genes13030420
000111705 0248_ $$2sideral$$a127802
000111705 037__ $$aART-2022-127802
000111705 041__ $$aeng
000111705 100__ $$0(orcid)0000-0001-6899-5938$$aSeral-Cortes, Miguel$$uUniversidad de Zaragoza
000111705 245__ $$aMediterranean Diet and Genetic Determinants of Obesity and Metabolic Syndrome in European Children and Adolescents
000111705 260__ $$c2022
000111705 5060_ $$aAccess copy available to the general public$$fUnrestricted
000111705 5203_ $$aChildhood obesity and metabolic syndrome (MetS) are multifactorial diseases influenced by genetic and environmental factors. The Mediterranean Diet (MD) seems to modulate the genetic predisposition to obesity or MetS in European adults. The FTO gene has also been shown to have an impact on the MD benefits to avoid obesity or MetS. Since these interaction effects have been scarcely analyzed in European youth, the aim was to describe the gene–MD interplay, analyzing the impact of the genetic factors to reduce the obesity and MetS risk through MD adherence, and the MD impact in the obesity and MetS genetic profile. From the limited evidence on gene–MD interaction studies in European youth, a study showed that the influence of high MD adherence on adiposity and MetS was only observed with a limited number of risk alleles; the gene–MD interplay showed sex-specific differences, being higher in females. Most results analyzed in European adults elucidate that, the relationship between MD adherence and both obesity and MetS risk, could be modulated by obesity genetic variants and vice versa. Further research is needed, to better understand the inter-individual differences in the association between MD and body composition, and the integration of omics and personalized nutrition considering MD.
000111705 536__ $$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent
000111705 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000111705 590__ $$a3.5$$b2022
000111705 592__ $$a0.924$$b2022
000111705 591__ $$aGENETICS & HEREDITY$$b66 / 171 = 0.386$$c2022$$dQ2$$eT2
000111705 593__ $$aGenetics (clinical)$$c2022$$dQ2
000111705 593__ $$aGenetics$$c2022$$dQ2
000111705 594__ $$a5.1$$b2022
000111705 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000111705 700__ $$aLarruy-García, Alicia$$uUniversidad de Zaragoza
000111705 700__ $$0(orcid)0000-0001-6173-5850$$aDe Miguel-Etayo, Pilar$$uUniversidad de Zaragoza
000111705 700__ $$aLabayen, Idoia
000111705 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000111705 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000111705 773__ $$g13, 3 (2022), 420 [19 pp.]$$pGenes (Basel)$$tGenes$$x2073-4425
000111705 8564_ $$s1202715$$uhttps://zaguan.unizar.es/record/111705/files/texto_completo.pdf$$yVersión publicada
000111705 8564_ $$s2733484$$uhttps://zaguan.unizar.es/record/111705/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000111705 909CO $$ooai:zaguan.unizar.es:111705$$particulos$$pdriver
000111705 951__ $$a2024-03-18-14:04:49
000111705 980__ $$aARTICLE