000112025 001__ 112025
000112025 005__ 20230519145547.0
000112025 0247_ $$2doi$$a10.3390/ijerph18137092
000112025 0248_ $$2sideral$$a127105
000112025 037__ $$aART-2021-127105
000112025 041__ $$aeng
000112025 100__ $$0(orcid)0000-0002-1252-2397$$aLobo, E.$$uUniversidad de Zaragoza
000112025 245__ $$aDifferences in trajectories and predictive factors of cognition over time in a sample of cognitively healthy adults, in zaragoza, spain
000112025 260__ $$c2021
000112025 5060_ $$aAccess copy available to the general public$$fUnrestricted
000112025 5203_ $$aGreat inter-individual variability has been reported in the maintenance of cognitive function in aging. We examined this heterogeneity by modeling cognitive trajectories in a population-based longitudinal study of adults aged 55+ years. We hypothesized that (1) distinct classes of cognitive trajectories would be found, and (2) between-class differences in associated factors would be ob-served. The sample comprised 2403 cognitively healthy individuals from the Zaragoza Dementia and Depression (ZARADEMP) project, who had at least three measurements of the Mini-Mental State Examination (MMSE) in a 12-year follow-up. Longitudinal changes in cognitive functioning were modeled using growth mixture models (GMM) in the data. The best-fitting age-adjusted model showed 3 distinct trajectories, with 1-high-to-moderate (21.2% of participants), 2-moderate-stable (67.5%) and, 3-low-and-declining (9.9%) cognitive function over time, respectively. Compared with the reference 2-trajectory, the association of education and depression was significantly different in trajectories 1 and 3. Instrumental activities of daily living (iADLs) were only associated with the declining trajectory. This suggests that intervention strategies should be tailored specifically to individuals with different trajectories of cognitive aging, and intervention strategies designed to maintain cognitive function might be different from those to prevent decline. A stable cognitive performance (‘successful cognitive aging’) rather than a mild decline, might be more ‘normal’ than generally expected.
000112025 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI-19-01874$$9info:eu-repo/grantAgreement/ES/DGA/B15-17R
000112025 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000112025 590__ $$a4.614$$b2021
000112025 592__ $$a0.814$$b2021
000112025 594__ $$a4.5$$b2021
000112025 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b45 / 183 = 0.246$$c2021$$dQ1$$eT1
000112025 593__ $$aPollution$$c2021$$dQ1
000112025 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b71 / 210 = 0.338$$c2021$$dQ2$$eT2
000112025 593__ $$aHealth, Toxicology and Mutagenesis$$c2021$$dQ1
000112025 591__ $$aENVIRONMENTAL SCIENCES$$b100 / 279 = 0.358$$c2021$$dQ2$$eT2
000112025 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000112025 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, P.$$uUniversidad de Zaragoza
000112025 700__ $$0(orcid)0000-0003-3025-8048$$aLobo, A.$$uUniversidad de Zaragoza
000112025 700__ $$0(orcid)0000-0002-6427-6845$$aSaz, P.$$uUniversidad de Zaragoza
000112025 700__ $$0(orcid)0000-0003-2284-7862$$ade-la-Cámara, C.$$uUniversidad de Zaragoza
000112025 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000112025 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000112025 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000112025 773__ $$g18, 13 (2021), 18137092 [13 pp.]$$pInt. j. environ. res. public health$$tInternational journal of environmental research and public health$$x1661-7827
000112025 8564_ $$s666993$$uhttps://zaguan.unizar.es/record/112025/files/texto_completo.pdf$$yVersión publicada
000112025 8564_ $$s2691980$$uhttps://zaguan.unizar.es/record/112025/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000112025 909CO $$ooai:zaguan.unizar.es:112025$$particulos$$pdriver
000112025 951__ $$a2023-05-18-15:46:03
000112025 980__ $$aARTICLE