112025 20230519145547.0 doi 10.3390/ijerph18137092 sideral 127105 ART-2021-127105 eng Lobo, E. Universidad de Zaragoza (orcid)0000-0002-1252-2397 Differences in trajectories and predictive factors of cognition over time in a sample of cognitively healthy adults, in zaragoza, spain 2021 Access copy available to the general public Unrestricted Great inter-individual variability has been reported in the maintenance of cognitive function in aging. We examined this heterogeneity by modeling cognitive trajectories in a population-based longitudinal study of adults aged 55+ years. We hypothesized that (1) distinct classes of cognitive trajectories would be found, and (2) between-class differences in associated factors would be ob-served. The sample comprised 2403 cognitively healthy individuals from the Zaragoza Dementia and Depression (ZARADEMP) project, who had at least three measurements of the Mini-Mental State Examination (MMSE) in a 12-year follow-up. Longitudinal changes in cognitive functioning were modeled using growth mixture models (GMM) in the data. The best-fitting age-adjusted model showed 3 distinct trajectories, with 1-high-to-moderate (21.2% of participants), 2-moderate-stable (67.5%) and, 3-low-and-declining (9.9%) cognitive function over time, respectively. Compared with the reference 2-trajectory, the association of education and depression was significantly different in trajectories 1 and 3. Instrumental activities of daily living (iADLs) were only associated with the declining trajectory. This suggests that intervention strategies should be tailored specifically to individuals with different trajectories of cognitive aging, and intervention strategies designed to maintain cognitive function might be different from those to prevent decline. A stable cognitive performance (‘successful cognitive aging’) rather than a mild decline, might be more ‘normal’ than generally expected. info:eu-repo/grantAgreement/ES/DGA/B15-17R info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI-19-01874 info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255 info:eu-repo/grantAgreement/ES/ISCIII/FIS/03-0815 info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617 info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562 info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.614 2021 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 45 / 183 = 0.246 2021 Q1 T1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 71 / 210 = 0.338 2021 Q2 T2 ENVIRONMENTAL SCIENCES 100 / 279 = 0.358 2021 Q2 T2 0.814 2021 Pollution 2021 Q1 Health, Toxicology and Mutagenesis 2021 Q1 4.5 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gracia-García, P. Universidad de Zaragoza (orcid)0000-0001-9822-6312 Lobo, A. Universidad de Zaragoza (orcid)0000-0003-3025-8048 Saz, P. Universidad de Zaragoza (orcid)0000-0002-6427-6845 de-la-Cámara, C. Universidad de Zaragoza (orcid)0000-0003-2284-7862 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 18, 13 (2021), 18137092 [13 pp.] Int. j. environ. res. public health International journal of environmental research and public health 1661-7827 666993 http://zaguan.unizar.es/record/112025/files/texto_completo.pdf Versión publicada 2691980 http://zaguan.unizar.es/record/112025/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:112025 articulos driver 2023-05-18-15:46:03 ARTICLE