000112033 001__ 112033
000112033 005__ 20230519145548.0
000112033 0247_ $$2doi$$a10.1016/j.heliyon.2021.e07204
000112033 0248_ $$2sideral$$a127092
000112033 037__ $$aART-2021-127092
000112033 041__ $$aeng
000112033 100__ $$0(orcid)0000-0001-6140-2423$$aMachicado C.
000112033 245__ $$aIn silico prediction of secretory proteins of Opisthorchis viverrini, Clonorchis sinensis and Fasciola hepatica that target the host cell nucleus
000112033 260__ $$c2021
000112033 5060_ $$aAccess copy available to the general public$$fUnrestricted
000112033 5203_ $$aLiver flukes Fasciola hepatica, Opisthorchis viverrini and Clonorchis sinensis are causing agents of liver and hepatobiliary diseases. A remarkable difference between such worms is the fact that O. viverrini and C. sinensis are carcinogenic organisms whereas F. hepatica is not carcinogenic. The release of secretory factors by carcinogenic flukes seems to contribute to cancer development however if some of these target the host cell nuclei is unknown. We investigated the existence of O. viverrini and C. sinensis secretory proteins that target the nucleus of host cells and compared these with the corresponding proteins predicted in F. hepatica. Here we applied an algorithm composed by in silico approaches that screened and analyzed the potential genes predicted from genomes of liver flukes. We found 31 and 22 secretory proteins that target the nucleus of host cells in O. viverrini and C. sinensis, respectively, and that have no homologs in F. hepatica. These polypeptides have enriched the transcription initiation process and nucleic acid binding in O. viverrini and C. sinensis, respectively. In addition, other 11 secretory proteins of O. viverrini and C. sinensis, that target the nucleus of host cells, had F. hepatica homologs, have enriched RNA processing function. In conclusion, O. viverrini and C. sinensis have 31 and 22 genes, respectively, that may be involved in their carcinogenic action through a direct targeting on the host cell nuclei. © 2021 The Author(s)
000112033 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000112033 590__ $$a3.776$$b2021
000112033 592__ $$a0.55$$b2021
000112033 591__ $$aMULTIDISCIPLINARY SCIENCES$$b28 / 74 = 0.378$$c2021$$dQ2$$eT2
000112033 593__ $$aMultidisciplinary$$c2021$$dQ1
000112033 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000112033 700__ $$aSoto M.P.
000112033 700__ $$aLa Chira L.F.
000112033 700__ $$aTorres J.
000112033 700__ $$aMendoza C.
000112033 700__ $$aMarcos L.A.
000112033 773__ $$g7, 7 (2021), e07204$$pHeliyon$$tHeliyon$$x2405-8440
000112033 8564_ $$s690494$$uhttps://zaguan.unizar.es/record/112033/files/texto_completo.pdf$$yVersión publicada
000112033 8564_ $$s2588108$$uhttps://zaguan.unizar.es/record/112033/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000112033 909CO $$ooai:zaguan.unizar.es:112033$$particulos$$pdriver
000112033 951__ $$a2023-05-18-15:47:38
000112033 980__ $$aARTICLE