000112087 001__ 112087
000112087 005__ 20240319080951.0
000112087 0247_ $$2doi$$a10.1016/j.compbiomed.2022.105304
000112087 0248_ $$2sideral$$a128265
000112087 037__ $$aART-2022-128265
000112087 041__ $$aeng
000112087 100__ $$aBukhari, Hassaan A.
000112087 245__ $$aEstimation of potassium levels in hemodialysis patients by T wave nonlinear dynamics and morphology markers
000112087 260__ $$c2022
000112087 5060_ $$aAccess copy available to the general public$$fUnrestricted
000112087 5203_ $$aNoninvasive screening of hypo- and hyperkalemia can prevent fatal arrhythmia in end-stage renal disease (ESRD) patients, but current methods for monitoring of serum potassium (K+) have important limitations. We investigated changes in nonlinear dynamics and morphology of the T wave in the electrocardiogram (ECG) of ESRD patients during hemodialysis (HD), assessing their relationship with K+ and designing a K+ estimator. Methods: ECG recordings from twenty-nine ESRD patients undergoing HD were processed. T waves in 2-min windows were extracted at each hour during an HD session as well as at 48 h after HD start. T wave nonlinear dynamics were characterized by two indices related to the maximum Lyapunov exponent (¿t, ¿wt) and a divergence-related index (¿). Morphological variability in the T wave was evaluated by three time warping-based indices (dw, reflecting morphological variability in the time domain, and da and daNL, in the amplitude domain). K+was measured from blood samples extracted during and after HD. Stage-specific and patient-specific K+ estimators were built based on the quantified indices and leave-one-out cross-validation was performed separately for each of the estimators. Results: The analyzed indices showed high inter-individual variability in their relationship with K+. Nevertheless, all of them had higher values at the HD start and 48 h after it, corresponding to the highest K+. The indices ¿ and dw were the most strongly correlated with K+ (median Pearson correlation coefficient of 0.78 and 0.83, respectively) and were used in univariable and multivariable linear K+ estimators. Agreement between actual and estimated K+ was confirmed, with averaged errors over patients and time points being 0.000 ± 0.875 mM and 0.046 ± 0.690 mM for stage-specific and patient-specific multivariable K+ estimators, respectively.ariability allow noninvasive
monitoring of [K+] in ESRD patients.
Significance: ECG markers have the potential to be used for hypo- and hyperkalemia screening in ESRD patients
000112087 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/LMP124-18$$9info:eu-repo/grantAgreement/EC/H2020/764738/EU/Personalised In-Silico Cardiology/PIC$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 764738-PIC$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-104881RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-105674RB-I00
000112087 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000112087 590__ $$a7.7$$b2022
000112087 592__ $$a1.222$$b2022
000112087 591__ $$aBIOLOGY$$b7 / 92 = 0.076$$c2022$$dQ1$$eT1
000112087 593__ $$aHealth Informatics$$c2022$$dQ1
000112087 591__ $$aMATHEMATICAL & COMPUTATIONAL BIOLOGY$$b4 / 55 = 0.073$$c2022$$dQ1$$eT1
000112087 593__ $$aComputer Science Applications$$c2022$$dQ1
000112087 591__ $$aENGINEERING, BIOMEDICAL$$b16 / 96 = 0.167$$c2022$$dQ1$$eT1
000112087 591__ $$aCOMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS$$b18 / 110 = 0.164$$c2022$$dQ1$$eT1
000112087 594__ $$a9.2$$b2022
000112087 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000112087 700__ $$aSánchez, Carlos
000112087 700__ $$aSrinivasan, Sabarathinam
000112087 700__ $$aPalmieri, Flavio
000112087 700__ $$aPotse, Mark
000112087 700__ $$aLaguna, Pablo
000112087 700__ $$aPueyo, Esther
000112087 773__ $$g143 (2022), 105304 [13 pp]$$pComput. biol. med.$$tComputers in biology and medicine$$x0010-4825
000112087 8564_ $$s6641334$$uhttps://zaguan.unizar.es/record/112087/files/texto_completo.pdf$$yVersión publicada
000112087 8564_ $$s2176527$$uhttps://zaguan.unizar.es/record/112087/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000112087 909CO $$ooai:zaguan.unizar.es:112087$$particulos$$pdriver
000112087 951__ $$a2024-03-18-13:05:03
000112087 980__ $$aARTICLE