000112092 001__ 112092
000112092 005__ 20230914083400.0
000112092 0247_ $$2doi$$a10.3390/ijerph19010363
000112092 0248_ $$2sideral$$a128205
000112092 037__ $$aART-2022-128205
000112092 041__ $$aeng
000112092 100__ $$aPerez-Gomez, Jorge
000112092 245__ $$aNew Evidence on Regucalcin, Body Composition, and Walking Ability Adaptations to Multicomponent Exercise Training in Functionally Limited and Frail Older Adults
000112092 260__ $$c2022
000112092 5060_ $$aAccess copy available to the general public$$fUnrestricted
000112092 5203_ $$aBackground: Regucalcin, or senescence marker protein-30 (SMP30), is a Ca2+-binding protein with multiple functions reported in the literature. Physical exercise has been shown to improve aging markers; nevertheless, SMP30 in humans has not been extensively researched. Older adults experience a decline in functional capacity and body composition. The purpose of this study was to examine the effects of a multicomponent training (MCT) program on SMP30 and its regulation of walking ability and body composition in functionally limited, frail, and pre-frail older adults. Methods: A total of 34 older adults (aged 80.3 +/- 6.1 years) were divided into an intervention group (IG = 20) and control group (CG = 14). The IG performed a supervised MCT (strength, endurance, balance, coordination, and flexibility) program for 6 months, 3 days per week, whereas the CG continued their normal lives without any specific physical training. SMP30 was analyzed in plasma after 3 and 6 months of MCT, while some physical fitness variables (Timed Up and Go (TUG) and 6-min walk test (6MWT)) and body composition (fat mass and lean mass) were measured at baseline, as well as after 3 months and 6 months of MCT. Results: No significant changes were observed in SPM30 between the IG (877.5 a.u. to 940.5 a.u., respectively) and CG (790.4 a.u. to 763.8 a.u., respectively). Moreover, no SMP30 differences were found between groups after 3 and 6 months of MCT. The IG improved significantly in the 6MWT after 3 months (472.2 +/- 84.2 m) compared to baseline (411.2 +/- 75.2 m). The IG also significantly enhanced their TUG performance after 3 months (7.6 +/- 1.6 s) and 6 months (7.3 +/- 1.8 s) of training compared to baseline (9.3 +/- 3.2 s) (all, p < 0.001). There were no significant differences in body composition between the IG and CG through the 6 months of MCT. Conclusions: The present study suggests that MCT did not change SMP30 levels from 3 to 6 months, where there were changes in neither walking ability nor body composition; however, MCT was effective in improving 6MWT and TUG performance from baseline to 3 months.
000112092 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000112092 592__ $$a0.828$$b2022
000112092 593__ $$aHealth, Toxicology and Mutagenesis$$c2022$$dQ2
000112092 593__ $$aPublic Health, Environmental and Occupational Health$$c2022$$dQ2
000112092 593__ $$aPollution$$c2022$$dQ2
000112092 594__ $$a5.4$$b2022
000112092 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000112092 700__ $$aRedondo, Pedro C.
000112092 700__ $$aNavarrete-Villanueva, David
000112092 700__ $$aLozano-Berges, Gabriel
000112092 700__ $$aAra, Ignacio
000112092 700__ $$aGonzalez-Gross, Marcela
000112092 700__ $$aCasajus, Jose A.
000112092 700__ $$0(orcid)0000-0002-4303-4097$$aVicente-Rodriguez, German$$uUniversidad de Zaragoza
000112092 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000112092 773__ $$g19, 1 (2022), 363 [9 pp]$$pInt. j. environ. res. public health$$tInternational journal of environmental research and public health$$x1661-7827
000112092 8564_ $$s359974$$uhttps://zaguan.unizar.es/record/112092/files/texto_completo.pdf$$yVersión publicada
000112092 8564_ $$s2910395$$uhttps://zaguan.unizar.es/record/112092/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000112092 909CO $$ooai:zaguan.unizar.es:112092$$particulos$$pdriver
000112092 951__ $$a2023-09-13-11:40:09
000112092 980__ $$aARTICLE