000112112 001__ 112112
000112112 005__ 20240319080956.0
000112112 0247_ $$2doi$$a10.1186/s12887-021-03041-z
000112112 0248_ $$2sideral$$a128082
000112112 037__ $$aART-2022-128082
000112112 041__ $$aeng
000112112 100__ $$aCordoba-Rodriguez, Diana Paola
000112112 245__ $$aFat-free/lean body mass in children with insulin resistance or metabolic syndrome: a systematic review and meta-analysis
000112112 260__ $$c2022
000112112 5060_ $$aAccess copy available to the general public$$fUnrestricted
000112112 5203_ $$aBackground: Lean / Fat Free Body Mass (LBM) is metabolically involved in active processes such as resting energy expenditure, glucose uptake, and myokine secretion. Nonetheless, its association with insulin sensitivity / resistance / glucose tolerance and metabolic syndrome remains unclear in childhood. Methods: The current investigation aimed to examine the differences in fat-free mass /lean body mass according to the presence of insulin sensitivity/insulin resistance/glucose tolerance/metabolic syndrome in children. A systematic search was carried out in Medline/PubMed, Embase, Scopus, Web of Science, and SciELO, covering the period from each database''s respective start to 21 June 2021. Two researchers evaluated 7111 studies according to the inclusion criteria: original human studies, written in English or Spanish, evaluating fat-free mass/lean body mass in children and adolescents including both with and without insulin sensitivity/insulin resistance /glucose tolerance and metabolic syndrome and reported the differences between them in terms of fat free mass/lean body mass. The results of the studies were combined with insulin sensitivity, insulin, resistance, glucose tolerance and metabolic syndrome. The standardized mean difference (SMD) in each study was calculated and combined using the random-effects model. Heterogeneity between studies was tested using the index of heterogeneity (I-2), leave-one-out sensitivity analyses were performed, and publication bias was assessed using the Egger and Begg tests. Results: Finally, 15 studies which compared groups defined according to different glucose homeostasis criteria or metabolic syndrome out of 103 eligible studies were included in this systematic review and 12 studies in the meta-analysis. Meta-analysis showed lower fat-free mass/lean body mass percentage in participants with insulin resistance/glucose tolerance/metabolic syndrome (SMD -0.47; 95% CI, - 0.62 to - 0.32) while in mass units (kg), higher values were found in the same group (SMD, 1.01; 95% CI, 0.43 to 1.60). Conclusions: Our results identified lower values of fat-free mass/lean body mass (%) in children and adolescents with insulin resistance/glucose tolerance/metabolic syndrome and higher values of fat-free mass/lean body mass when these are expressed in kg. The evidence of the impact of lean mass on children''s glucose homeostasis or metabolic syndrome is limited, so future studies research should focus on explaining the effect of fat-free mass/lean body mass on different metabolic outcomes. Moreover, it may be interesting to evaluate the quality (muscle density) or functional (muscle strength) outcomes in addition to both absolute (kg) and relative (%) values in future studies.
000112112 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000112112 590__ $$a2.4$$b2022
000112112 592__ $$a0.742$$b2022
000112112 591__ $$aPEDIATRICS$$b58 / 130 = 0.446$$c2022$$dQ2$$eT2
000112112 593__ $$aPediatrics, Perinatology and Child Health$$c2022$$dQ1
000112112 594__ $$a3.7$$b2022
000112112 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000112112 700__ $$0(orcid)0000-0002-2219-3646$$aIglesia Altaba, Iris
000112112 700__ $$0(orcid)0000-0002-0520-1640$$aGómez Brutón, Alejandro$$uUniversidad de Zaragoza
000112112 700__ $$0(orcid)0000-0002-7985-9912$$aRodriguez Martínez, Gerardo$$uUniversidad de Zaragoza
000112112 700__ $$0(orcid)0000-0002-7215-6931$$aCasajús Mallén, Jose Antonio$$uUniversidad de Zaragoza
000112112 700__ $$aMorales-Devia, Hernan
000112112 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno Aznar, Luis A.$$uUniversidad de Zaragoza
000112112 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000112112 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000112112 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000112112 773__ $$g22, 58 (2022), [23 pp]$$pBMC PEDIATRICS$$tBMC PEDIATRICS$$x1471-2431
000112112 8564_ $$s2601199$$uhttps://zaguan.unizar.es/record/112112/files/texto_completo.pdf$$yVersión publicada
000112112 8564_ $$s2495685$$uhttps://zaguan.unizar.es/record/112112/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000112112 909CO $$ooai:zaguan.unizar.es:112112$$particulos$$pdriver
000112112 951__ $$a2024-03-18-13:40:00
000112112 980__ $$aARTICLE