112141 20220503133916.0 doi 10.1111/insr.12363 sideral 117436 ART-2020-117436 eng Flournoy, Nancy Performance Measures in Dose-Finding Experiments 2020 In the first phase of pharmaceutical development, and assuming that the probability of positive response increases with dose, the main statistical goal is to estimate a percentile of the dose–response function for a given target ¿. We compare the Maximum Likelihood and centred isotonic regression estimators of the target dose and we discuss several performance criteria to assess inferential precision, the amount of toxicity exposure and the trade-off between them for a set of some exemplary adaptive designs. We compare these designs using graphical tools. Several scenarios are considered using simulation, including the use of several start-up rules, the change of slope of the dose-toxicity function at the target dose and also different theoretical models, as logistic, normal or skew-normal distribution functions. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/MINECO/MTM2014-53340-P info:eu-repo/grantAgreement/ES/MINECO/MTM2016-77015-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.217 2020 STATISTICS & PROBABILITY 38 / 125 = 0.304 2020 Q2 T1 1.05 2020 Statistics, Probability and Uncertainty 2020 Q2 Statistics and Probability 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Moler, José Plo, Fernando Universidad de Zaragoza (orcid)0000-0003-2203-655X 2007 265 Universidad de Zaragoza Dpto. Métodos Estadísticos Área Estadís. Investig. Opera. 88, 3 (2020), 728-751 Int. stat. rev. INTERNATIONAL STATISTICAL REVIEW 0306-7734 2240184 http://zaguan.unizar.es/record/112141/files/texto_completo.pdf Versión publicada 2145485 http://zaguan.unizar.es/record/112141/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:112141 articulos driver 2022-05-03-12:27:24 ARTICLE