000112161 001__ 112161
000112161 005__ 20240319080950.0
000112161 0247_ $$2doi$$a10.3389/fped.2022.830035
000112161 0248_ $$2sideral$$a128410
000112161 037__ $$aART-2022-128410
000112161 041__ $$aeng
000112161 100__ $$0(orcid)0000-0002-9641-0324$$aRite Gracia, S.$$uUniversidad de Zaragoza
000112161 245__ $$aThe Consensus Definition of Bronchopulmonary Dysplasia Is an Adequate Predictor of Lung Function at Preschool Age
000112161 260__ $$c2022
000112161 5060_ $$aAccess copy available to the general public$$fUnrestricted
000112161 5203_ $$aBackground: Recent attempts to refine the definition bronchopulmonary dysplasia (BPD) have based its predictive capacity on respiratory outcome in the first 2 years of life, eliminating the pre-existing requirement of 28 days of oxygen therapy prior to 36 weeks postmenstrual age (PMA). The objective of this study was to assess the utility of the 2001 consensus definition in predicting impaired lung function at preschool age. Methods: This cohort study included children aged 4–6 years old who were born at gestational age (GA) <32 weeks or bodyweight <1500 g. Univariate and multivariate analyses were performed to assess differences in antenatal and neonatal variables between BPD and non-BPD children. All participants underwent incentive spirometry. Lung function parameters were contrasted with the Global Lung Function Initiative (GLI-2012) reference equations and, together with antenatal and neonatal variables, compared among the different subgroups (no BPD, mild BPD, and moderate-to-severe BPD). A multivariate model was generated to identify independent risk factors for impaired lung function. Results: GA, hemodynamically significant patent ductus arteriosus, and late sepsis were independent risk factors for the development of BPD. A total of 119 children underwent incentive spirometry. All lung function parameters were significantly altered relative to reference values. Greater impairment of lung function was observed in the mild BPD vs. the no BPD group (forced expiratory volume in the first 0.75 seconds FEV0.75]: -1.18 ± 0.80 vs. -0.55 ± 1.13; p = 0.010), but no difference in forced vital capacity (FVC) was observed (-0.32 ± 0.90 vs. -0.18 ± 1; p = 0.534). The moderate-to-severe BPD group exhibited the most severe FEV0.75 reduction (FEV0.75: -2.63 ± 1.18 vs. -0.72 ± 1.08; p = 0.000) and was the only condition with FVC impairment (FVC: -1.82 ± 1.12 vs. -0.22 ± 0.87; p = 0.000). The multivariate analysis identified a diagnosis of moderate-to-severe BPD as an independent risk factor for lung function impairment. Conclusion: The 2001 consensus definition of BPD has adequate predictive capacity for lung function measured by spirometry at 4–6 years of age. Moderate-to-severe BPD was the best predictor of respiratory impairment. Children with mild BPD showed greater alteration of FEV0.75 than those without BPD. Copyright © 2022 Rite, Martín de Vicente, García-Iñiguez, Couce, Samper, Montaner and Ruiz de la Cuesta.
000112161 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000112161 590__ $$a2.6$$b2022
000112161 592__ $$a0.798$$b2022
000112161 591__ $$aPEDIATRICS$$b48 / 130 = 0.369$$c2022$$dQ2$$eT2
000112161 593__ $$aPediatrics, Perinatology and Child Health$$c2022$$dQ1
000112161 594__ $$a3.3$$b2022
000112161 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000112161 700__ $$aMartín de Vicente, C.
000112161 700__ $$aGarcía-Iñiguez, J. P.
000112161 700__ $$aCouce, M. L.
000112161 700__ $$0(orcid)0000-0001-5492-3191$$aSamper Villagrasa, M. P.$$uUniversidad de Zaragoza
000112161 700__ $$aMontaner, A.
000112161 700__ $$aRuiz de la Cuesta, C.
000112161 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000112161 773__ $$g10 (2022), 830035 [9p]$$pFront. pediatr.$$tFRONTIERS IN PEDIATRICS$$x2296-2360
000112161 8564_ $$s900015$$uhttps://zaguan.unizar.es/record/112161/files/texto_completo.pdf$$yVersión publicada
000112161 8564_ $$s2407489$$uhttps://zaguan.unizar.es/record/112161/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000112161 909CO $$ooai:zaguan.unizar.es:112161$$particulos$$pdriver
000112161 951__ $$a2024-03-18-12:59:26
000112161 980__ $$aARTICLE