112188 20240319080958.0 doi 10.3390/cancers14071828 sideral 128327 ART-2022-128327 eng Morote, Juan Multiparametric Magnetic Resonance Imaging Grades the Aggressiveness of Prostate Cancer 2022 Access copy available to the general public Unrestricted We sought to find further evidence showing the increase in PCa aggressiveness as PI-RADS score increases from four surrogates of PCa aggressiveness: i. prostate biopsy GG (≤3 vs. >3), ii. type of pathology in surgical specimens (favourable vs. unfavourable), iii. clinical stage (localised vs. advanced), and risk of recurrence of localised PCa after primary treatment (low-intermediate vs. high). A group of 692 PCa patients were diagnosed after 3-T multiparametric MRI (mpMRI) and guided and/or systematic biopsies, showing csPCa (GG ≥ 2) in 547 patients (79%) and insignificant PCa (iPCa) in 145 (21%). The csPCa rate increased from 32.4% in PI-RADS < 3 to 95.5% in PI-RADS 5 (p < 0.001). GG ≥ 3 was observed in 7.6% of PCa with PI-RADS < 3 and 32.6% in those with PI-RADS > 3 (p < 0.001). Unfavourable pathology was observed in 38.9% of PCa with PI-RAD < 3 and 68.3% in those with PI-RADS > 3 (p = 0.030). Advanced disease was not observed in PCa with PI-RADS ≤ 3, while it existed in 12.7% of those with PI-RADS > 3 (p < 0.001). High-risk recurrence localised PCa was observed in 9.5% of PCa with PI-RADS < 3 and 35% in those with PI-RADS > 3 (p = 0.001). The PI-RADS score was an independent predictor of all surrogates of PCa aggressiveness as PSA density. We confirmed that mpMRI grades PCa aggressiveness. info:eu-repo/grantAgreement/ES/ISCIII/PI20/01666 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.2 2022 ONCOLOGY 72 / 241 = 0.299 2022 Q2 T1 1.312 2022 Oncology 2022 Q1 Cancer Research 2022 Q2 7.4 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Borque-Fernando, Angel Universidad de Zaragoza (orcid)0000-0003-0178-4567 Triquell, Marina Celma, Anna Regis, Lucas Mast, Richard de Torres, Inés M. Semidey, María E. Santamaría, Anna Planas, Jacques Esteban, Luis M. (orcid)0000-0002-3007-302X Trilla, Enrique 1013 817 Universidad de Zaragoza Dpto. Cirugía Área Urología 14, 7 (2022), 1828 [9 p.] Cancers Cancers 2072-6694 619453 http://zaguan.unizar.es/record/112188/files/texto_completo.pdf Versión publicada 2647704 http://zaguan.unizar.es/record/112188/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:112188 articulos driver 2024-03-18-13:54:03 ARTICLE