000112447 001__ 112447
000112447 005__ 20240319080951.0
000112447 0247_ $$2doi$$a10.1016/j.jmbbm.2021.105043
000112447 0248_ $$2sideral$$a128375
000112447 037__ $$aART-2022-128375
000112447 041__ $$aeng
000112447 100__ $$aBeltrán, Gabriel
000112447 245__ $$aMechanical modeling of lung alveoli: from macroscopic behaviour to cell mechano-sensing at microscopic level
000112447 260__ $$c2022
000112447 5060_ $$aAccess copy available to the general public$$fUnrestricted
000112447 5203_ $$aThe mechanical signals sensed by the alveolar cells through the changes in the local matrix stiffness of the extracellular matrix (ECM) are determinant for regulating cellular functions. Therefore, the study of the mechanical response of lung tissue becomes a fundamental aspect in order to further understand the mechanosensing signals perceived by the cells in the alveoli. This study is focused on the development of a finite element (FE) model of a decellularized rat lung tissue strip, which reproduces accurately the mechanical behaviour observed in the experiments by means of a tensile test. For simulating the complex structure of the lung parenchyma, which consists of a heterogeneous and non-uniform network of thin-walled alveoli, a 3D model based on a Voronoi tessellation is developed. This Voronoi-based model is considered very suitable for recreating the geometry of cellular materials with randomly distributed polygons like in the lung tissue. The material model used in the mechanical simulations of the lung tissue was characterized experimentally by means of AFM tests in order to evaluate the lung tissue stiffness on the micro scale. Thus, in this study, the micro (AFM test) and the macro scale (tensile test) mechanical behaviour are linked through the mechanical simulation with the 3D FE model based on Voronoi tessellation. Finally, a micro-mechanical FE-based model is generated from the Voronoi diagram for studying the stiffness sensed by the alveolar cells in function of two independent factors: the stretch level of the lung tissue and the geometrical position of the cells on the extracellular matrix (ECM), distinguishing between pneumocyte type I and type II. We conclude that the position of the cells within the alveolus has a great influence on the local stiffness perceived by the cells. Alveolar cells located at the corners of the alveolus, mainly type II pneumocytes, perceive a much higher stiffness than those located in the flat areas of the alveoli, which correspond to type I pneumocytes. However, the high stiffness, due to the macroscopic lung tissue stretch, affects both cells in a very similar form, thus no significant differences between them have been observed.
000112447 536__ $$9info:eu-repo/grantAgreement/EC/H2020/812772 /EU/Biomechanics in health and disease: advanced physical tools for innovative early diagnosis/Phys2BioMed$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 812772 -Phys2BioMed$$9info:eu-repo/grantAgreement/EC/H2020/826494/EU/PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers/PRIMAGE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 826494-PRIMAGE$$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-094494-B-C21
000112447 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000112447 590__ $$a3.9$$b2022
000112447 592__ $$a0.725$$b2022
000112447 591__ $$aENGINEERING, BIOMEDICAL$$b44 / 96 = 0.458$$c2022$$dQ2$$eT2
000112447 593__ $$aBiomaterials$$c2022$$dQ2
000112447 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b27 / 45 = 0.6$$c2022$$dQ3$$eT2
000112447 593__ $$aMechanics of Materials$$c2022$$dQ2
000112447 593__ $$aBiomedical Engineering$$c2022$$dQ2
000112447 594__ $$a6.8$$b2022
000112447 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000112447 700__ $$aNavajas, Daniel
000112447 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar, José Manuel$$uUniversidad de Zaragoza
000112447 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000112447 773__ $$g126 (2022), 105043 [8 pp]$$pJ. mech. behav. boomed. mater.$$tJournal of the Mechanical Behavior of Biomedical Materials$$x1751-6161
000112447 8564_ $$s3385259$$uhttps://zaguan.unizar.es/record/112447/files/texto_completo.pdf$$yVersión publicada
000112447 8564_ $$s2888643$$uhttps://zaguan.unizar.es/record/112447/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000112447 909CO $$ooai:zaguan.unizar.es:112447$$particulos$$pdriver
000112447 951__ $$a2024-03-18-13:03:02
000112447 980__ $$aARTICLE