000112737 001__ 112737
000112737 005__ 20230519145434.0
000112737 0247_ $$2doi$$a10.1136/bmjopen-2021-053983
000112737 0248_ $$2sideral$$a127518
000112737 037__ $$aART-2021-127518
000112737 041__ $$aeng
000112737 100__ $$aParedes, Igor
000112737 245__ $$aImpact of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients: A nationwide study in Spain
000112737 260__ $$c2021
000112737 5060_ $$aAccess copy available to the general public$$fUnrestricted
000112737 5203_ $$aObjective To assess the effect of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients in Spain. Settings The initial flood of COVID-19 patients overwhelmed an unprepared healthcare system. Different measures were taken to deal with this overburden. The effect of these measures on neurosurgical patients, as well as the effect of COVID-19 itself, has not been thoroughly studied. Participants This was a multicentre, nationwide, observational retrospective study of patients who underwent any neurosurgical operation from March to July 2020. Interventions An exploratory factorial analysis was performed to select the most relevant variables of the sample. Primary and secondary outcome measures Univariate and multivariate analyses were performed to identify independent predictors of mortality and postoperative SARS-CoV-2 infection. Results Sixteen hospitals registered 1677 operated patients. The overall mortality was 6.4%, and 2.9% (44 patients) suffered a perioperative SARS-CoV-2 infection. Of those infections, 24 were diagnosed postoperatively. Age (OR 1.05), perioperative SARS-CoV-2 infection (OR 4.7), community COVID-19 incidence (cases/10 5 people/week) (OR 1.006), postoperative neurological worsening (OR 5.9), postoperative need for airway support (OR 5.38), ASA grade =3 (OR 2.5) and preoperative GCS 3-8 (OR 2.82) were independently associated with mortality. For SARS-CoV-2 postoperative infection, screening swab test <72 hours preoperatively (OR 0.76), community COVID-19 incidence (cases/10 5 people/week) (OR 1.011), preoperative cognitive impairment (OR 2.784), postoperative sepsis (OR 3.807) and an absence of postoperative complications (OR 0.188) were independently associated. Conclusions Perioperative SARS-CoV-2 infection in neurosurgical patients was associated with an increase in mortality by almost fivefold. Community COVID-19 incidence (cases/10 5 people/week) was a statistically independent predictor of mortality. Trial registration number CEIM 20/217.
000112737 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000112737 590__ $$a3.007$$b2021
000112737 592__ $$a0.982$$b2021
000112737 594__ $$a3.9$$b2021
000112737 591__ $$aMEDICINE, GENERAL & INTERNAL$$b86 / 172 = 0.5$$c2021$$dQ2$$eT2
000112737 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000112737 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000112737 700__ $$aCastaño Leon, Ana Maria
000112737 700__ $$aLagares, Alfonso
000112737 700__ $$aJimenez Roldan, Luis
000112737 700__ $$aPerez-Nuñez, Angel
000112737 700__ $$aGonzález-Leon, Pedro
000112737 700__ $$aDelgado-Fernandez, Juan
000112737 700__ $$aEiriz, Carla
000112737 700__ $$aGarcía-Pérez, Daniel
000112737 700__ $$aMoreno-Gomez, Luis Miguel
000112737 700__ $$aEsteban-Sinovas, Olga
000112737 700__ $$aDelgado-López, Pedro
000112737 700__ $$aMartín-Alonso, Javier
000112737 700__ $$aKaen, Ariel
000112737 700__ $$aTirado-Caballero, Jorge
000112737 700__ $$aOrdóñez Carmona, Marta
000112737 700__ $$aArteaga Romero, Francisco
000112737 700__ $$aGonzalez Pombo, Marta
000112737 700__ $$aAlén, José F
000112737 700__ $$aGil-Simoes, Ricardo
000112737 700__ $$aTorres, Cristina V
000112737 700__ $$aNavas Garcia, Marta
000112737 700__ $$aBlasco, Guillermo
000112737 700__ $$aFrade-Porto, Natalia
000112737 700__ $$aGonzález-Tarno, Patricia
000112737 700__ $$aMartin Segura, Adrian
000112737 700__ $$aGelabert-Gonzalez, Miguel
000112737 700__ $$aMenendez Cortezon, Beatriz
000112737 700__ $$aRodriguez Botana, Brais
000112737 700__ $$aPérez-Alfayate, Rebeca
000112737 700__ $$aFernandez Garcia, Carla
000112737 700__ $$aFerrandez Pujante, Borja
000112737 700__ $$aVargas-Jiménez, Andres
000112737 700__ $$aCotúa, Carlos
000112737 700__ $$ade la Lama, Adolfo
000112737 700__ $$aCalero, Lourdes
000112737 700__ $$aRuiz-Juretschke, Fernando
000112737 700__ $$aGarcia Leal, Roberto
000112737 700__ $$aValera Mele, Marc
000112737 700__ $$aCasitas Hernando, Vicente
000112737 700__ $$aRivero Martín, Belén
000112737 700__ $$aOrduna, Javier$$uUniversidad de Zaragoza
000112737 700__ $$aCasado Pellejero, Juan$$uUniversidad de Zaragoza
000112737 700__ $$aFustero De Miguel, David$$uUniversidad de Zaragoza
000112737 700__ $$aDiaz-Molina, Jorge$$uUniversidad de Zaragoza
000112737 700__ $$aMoles Herbera, Jesus
000112737 700__ $$aCastello Ruiz, Maria Jose
000112737 700__ $$aGomar Alba, Mario
000112737 700__ $$aGarcia Perez, Fernando
000112737 700__ $$aHernandez Garcia, Borja Jesus
000112737 700__ $$aVillaseñor Ledezma, Javier
000112737 700__ $$aOtero Rodríguez, Álvaro
000112737 700__ $$aAilagas, Juan José
000112737 700__ $$aGoncalves-Estella, Jesús
000112737 700__ $$aSousa Casasnovas, Pablo
000112737 700__ $$aPascual Argente, Daniel
000112737 700__ $$aRuiz Martín, Laura
000112737 700__ $$aRoa Montes de Oca, Juan Carlos
000112737 700__ $$aArandia Guzmán, Daniel
000112737 700__ $$aGarcía Martín, Andoni
000112737 700__ $$aTorres Carretero, Luis
000112737 700__ $$aGarrido Ruíz, Patricia Alejandra
000112737 700__ $$aCalvo, Marta
000112737 700__ $$aMiranda-Lloret, Pablo
000112737 700__ $$aRodriguez-Cadarso Suarez-Vence, Miguel
000112737 700__ $$aAnotn Oltra, Joan
000112737 700__ $$aRoca Barber, Amparo
000112737 700__ $$aQuiroz Tejada, Arnold
000112737 700__ $$aCarbayo Lozano, Guillermo
000112737 700__ $$aBermudez Vilar, Garazi
000112737 700__ $$aPaternain Martin, Clara
000112737 700__ $$aDela FuenteVilla, Pablo
000112737 700__ $$aFidalgo De la Rosa, Marina
000112737 700__ $$aSistiaga García, Íñigo L
000112737 700__ $$aZabalo San Juan, Gorka
000112737 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000112737 773__ $$g11, 12 (2021), e053983 [12 pp.]$$pBMJ Open$$tBMJ Open$$x2044-6055
000112737 8564_ $$s576004$$uhttps://zaguan.unizar.es/record/112737/files/texto_completo.pdf$$yVersión publicada
000112737 8564_ $$s3204249$$uhttps://zaguan.unizar.es/record/112737/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000112737 951__ $$a2023-05-18-14:20:32
000112737 980__ $$aARTICLE