Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation

Arenas, M. Carmen ; Castro-Zavala, Adriana ; Martin-Sanchez, Ana ; Blanco-Gandia, Maria Carmen (Universidad de Zaragoza) ; Minarro, Jose ; Valverde, Olga ; Manzanedo, Carmen

Resumen: The prepulse inhibition (PPI) of the startle response can identify the rodents that are more sensitive to the effects of cocaine. Mice with a lower PPI presented a higher vulnerability to the effects of cocaine and a higher susceptibility to developing a substance use disorder (SUD). Maternal separation with early weaning (MSEW) is a relevant animal model to induce motivational alterations throughout life. Nevertheless, only a few studies on females exist, even though they are more vulnerable to stress- and cocaine-related problems. Hence, the aim of the present study was to evaluate the ability of PPI to identify females with a greater vulnerability to the longterm consequences of early stress on the motivational effects of cocaine. Female mice underwent MSEW and were classified according to their high or low PPI. They were then assessed in the cocaine-induced locomotor sensitization test, the conditioned place preference paradigm or the operant self-administration paradigm. Additionally, they were also evaluated in the passive avoidance task, the tail-suspension and the splash tests. The results revealed that the females with lower PPI presented higher consequences of MSEW on the effects of cocaine and showed an increase in anhedonia-like behaviours. Our findings support that a PPI deficit could represent a biomarker of vulnerability to the effects of cocaine induced by MSEW.

Idioma: Inglés

DOI: 10.1016/j.bbr.2021.113545

Año: 2022

Publicado en: Behavioural brain research 416 (2022), 113545 [13 pp.]
ISSN: 0166-4328

Factor impacto JCR: 2.7 (2022)

Categ. JCR: BEHAVIORAL SCIENCES rank: 20 / 52 = 0.385 (2022) - Q2 - T2
Categ. JCR: NEUROSCIENCES rank: 188 / 272 = 0.691 (2022) - Q3 - T3

Factor impacto CITESCORE: 6.2 - Neuroscience (Q2)

Factor impacto SCIMAGO: 0.881 - Behavioral Neuroscience (Q2)

Financiación: info:eu-repo/grantAgreement/ES/FEDER/Una manera de hacer Europa
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-0007
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-010
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83023
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75966

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Psicolog.Evolut.Educac (Dpto. Psicología y Sociología)