000112755 001__ 112755
000112755 005__ 20240319080954.0
000112755 0247_ $$2doi$$a10.1016/j.jcis.2021.09.064
000112755 0248_ $$2sideral$$a128054
000112755 037__ $$aART-2022-128054
000112755 041__ $$aeng
000112755 100__ $$0(orcid)0000-0002-9324-0446$$aAlejo, Teresa$$uUniversidad de Zaragoza
000112755 245__ $$aHybrid thermoresponsive nanoparticles containing drug nanocrystals for NIR-triggered remote release
000112755 260__ $$c2022
000112755 5060_ $$aAccess copy available to the general public$$fUnrestricted
000112755 5203_ $$aThe on-demand administration of anaesthetic drugs can be a promising alternative for chronic pain management. To further improve the efficacy of drug delivery vectors, high drug loadings combined with a spatiotemporal control on the release can not only relief the pain according to patient''s needs, but also improve the drawbacks of conventional burst release delivery systems. In this study, a hybrid nanomaterial was developed by loading bupivacaine nanocrystals (BNCs) into oligo(ethylene glycol) methyl ether methacrylate (OEGMA)-based thermoresponsive nanogels and coupling them to NIR-absorbing biodegradable copper sulphide nanoparticles (CuS NPs). Those CuS NPs were surface modified with polyelectrolytes using layer-by-layer techniques to be efficiently attached to the surface of nanogels by means of supramolecular interactions. The encapsulation of bupivacaine in the form of nanocrystals allowed to achieve CuS@BNC-nanogels having drug loadings as high as 65.5 wt%. The nanocrystals acted as longlasting drug reservoirs, leading to an elevated localized drug content, which was useful for their application in prolonged pain relief. The CuS@BNC-nanogels exhibited favorable photothermal transducing properties upon NIR-light irradiation. The photothermal effect granted by the CuS NPs triggered the nano-crystallized drug release to be boosted by the collapse of the thermoresponsive nanogels upon heating. Remote control was achieved for on-demand release at a specific time and place, indicating their potential use as an externally activated triggerable drug-delivery system. Furthermore, cell viability tests and flow cytometry analysis were performed showing satisfactory cytocompatibility in the dose-ranging study having a subcytotoxic concentration of 0.05 mg/mL for CuS@BNC-nanogels. This remotely activated nanoplatform is a promising strategy for long-lasting controlled analgesia and a potential alternative for clinical pain management. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license
000112755 536__ $$9info:eu-repo/grantAgreement/EUR/ERC-2013-CoG-614715$$9info:eu-repo/grantAgreement/ES/ISCIII-IIS/MS19-00092$$9info:eu-repo/grantAgreement/ES/MCIU/RTI2018-099019-A-I00
000112755 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000112755 590__ $$a9.9$$b2022
000112755 592__ $$a1.604$$b2022
000112755 591__ $$aCHEMISTRY, PHYSICAL$$b29 / 161 = 0.18$$c2022$$dQ1$$eT1
000112755 593__ $$aBiomaterials$$c2022$$dQ1
000112755 593__ $$aSurfaces, Coatings and Films$$c2022$$dQ1
000112755 593__ $$aElectronic, Optical and Magnetic Materials$$c2022$$dQ1
000112755 593__ $$aColloid and Surface Chemistry$$c2022$$dQ1
000112755 594__ $$a15.5$$b2022
000112755 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000112755 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, Victor$$uUniversidad de Zaragoza
000112755 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia
000112755 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000112755 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000112755 773__ $$g607, Part 2 (2022), 1466-1477$$pJ. colloid interface sci.$$tJournal of Colloid and Interface Science$$x0021-9797
000112755 8564_ $$s3174881$$uhttps://zaguan.unizar.es/record/112755/files/texto_completo.pdf$$yVersión publicada
000112755 8564_ $$s2325773$$uhttps://zaguan.unizar.es/record/112755/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000112755 909CO $$ooai:zaguan.unizar.es:112755$$particulos$$pdriver
000112755 951__ $$a2024-03-18-13:24:19
000112755 980__ $$aARTICLE