000117168 001__ 117168
000117168 005__ 20240319080958.0
000117168 0247_ $$2doi$$a10.1016/j.jcis.2022.03.036
000117168 0248_ $$2sideral$$a128425
000117168 037__ $$aART-2022-128425
000117168 041__ $$aeng
000117168 100__ $$0(orcid)0000-0002-1791-0188$$aBonet-Aleta, Javier$$uUniversidad de Zaragoza
000117168 245__ $$aGlutathione-Triggered catalytic response of Copper-Iron mixed oxide Nanoparticles. Leveraging tumor microenvironment conditions for chemodynamic therapy
000117168 260__ $$c2022
000117168 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117168 5203_ $$aHeterogeneous catalysis has emerged as a promising alternative for the development of new cancer therapies. In addition, regarding the tumor microenvironment as a reactor with very specific chemical features has provided a new perspective in the search for catalytic nanoarchitectures with specific action against chemical species playing a key role in tumor metabolism. One of these species is glutathione (GSH), whose depletion is the cornerstone of emerging strategies in oncology, since this metabolite plays a pivotal regulatory role as antioxidant agent, dampening the harmful effects of intracellular reactive oxidative species (ROS). Herein, we present copper-iron oxide spinel nanoparticles that exhibit a versatile and selective catalytic response to reduce GSH levels while generating ROS in a cascade reaction. We demonstrate a clear correlation between GSH depletion and apoptotic cell death in tumor cells in the presence of the copper-iron nanocatalyst. Furthermore, we also provide a novel analytical protocol, alternative to state-of-the-art commercial kits, to accurately monitoring the concentration of GSH intracellular levels in both tumor and healthy cells. We observe a selective action of the nanoparticles, with lower toxicity in healthy cell lines, whose intrinsic GSH levels are lower, and intense apoptosis in tumor cells accompanied by a fast reduction of GSH levels.
000117168 536__ $$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE
000117168 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000117168 590__ $$a9.9$$b2022
000117168 592__ $$a1.604$$b2022
000117168 591__ $$aCHEMISTRY, PHYSICAL$$b29 / 161 = 0.18$$c2022$$dQ1$$eT1
000117168 593__ $$aBiomaterials$$c2022$$dQ1
000117168 593__ $$aSurfaces, Coatings and Films$$c2022$$dQ1
000117168 593__ $$aElectronic, Optical and Magnetic Materials$$c2022$$dQ1
000117168 593__ $$aColloid and Surface Chemistry$$c2022$$dQ1
000117168 594__ $$a15.5$$b2022
000117168 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117168 700__ $$0(orcid)0000-0001-8762-5457$$aSancho-Albero, Maria
000117168 700__ $$0(orcid)0000-0002-1603-7305$$aCalzada-Funes, Javier$$uUniversidad de Zaragoza
000117168 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, Silvia$$uUniversidad de Zaragoza
000117168 700__ $$0(orcid)0000-0003-4160-9720$$aMartin-Duque, Pilar$$uUniversidad de Zaragoza
000117168 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, Jose L.$$uUniversidad de Zaragoza
000117168 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaria, Jesus$$uUniversidad de Zaragoza
000117168 7102_ $$11013$$2275$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Estomatología
000117168 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000117168 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000117168 773__ $$g617 (2022), 704-717$$pJ. colloid interface sci.$$tJournal of Colloid and Interface Science$$x0021-9797
000117168 8564_ $$s3425963$$uhttps://zaguan.unizar.es/record/117168/files/texto_completo.pdf$$yVersión publicada
000117168 8564_ $$s1879516$$uhttps://zaguan.unizar.es/record/117168/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117168 909CO $$ooai:zaguan.unizar.es:117168$$particulos$$pdriver
000117168 951__ $$a2024-03-18-13:53:34
000117168 980__ $$aARTICLE