000117195 001__ 117195
000117195 005__ 20230519145504.0
000117195 0247_ $$2doi$$a10.3762/bjnano.12.53
000117195 0248_ $$2sideral$$a126099
000117195 037__ $$aART-2021-126099
000117195 041__ $$aeng
000117195 100__ $$aPem, B
000117195 245__ $$aFate and transformation of silver nanoparticles in different biological conditions
000117195 260__ $$c2021
000117195 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117195 5203_ $$aThe exploitation of silver nanoparticles (AgNPs) in biomedicine represents more than one third of their overall application. Despite their wide use and significant amount of scientific data on their effects on biological systems, detailed insight into their in vivo fate is still lacking. This study aimed to elucidate the biotransformation patterns of AgNPs following oral administration. Colloidal stability, biochemical transformation, dissolution, and degradation behaviour of different types of AgNPs were evaluated in systems modelled to represent biological environments relevant for oral administration, as well as in cell culture media and tissue compartments obtained from animal models. A multimethod approach was employed by implementing light scattering (dynamic and electrophoretic) techniques, spectroscopy (UV-vis, atomic absorption, nuclear magnetic resonance) and transmission electron microscopy. The obtained results demonstrated that AgNPs may transform very quickly during their journey through different biological conditions. They are able to degrade to an ionic form and again reconstruct to a nanoparticulate form, depending on the biological environment determined by specific body compartments. As suggested for other inorganic nanoparticles by other research groups, AgNPs fail to preserve their specific integrity in in vivo settings.
000117195 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/BIO2017-84246-C2-1-R$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2015-17640
000117195 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117195 590__ $$a3.272$$b2021
000117195 592__ $$a0.664$$b2021
000117195 594__ $$a7.4$$b2021
000117195 591__ $$aPHYSICS, APPLIED$$b65 / 161 = 0.404$$c2021$$dQ2$$eT2
000117195 593__ $$aElectrical and Electronic Engineering$$c2021$$dQ2
000117195 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b75 / 109 = 0.688$$c2021$$dQ3$$eT3
000117195 593__ $$aPhysics and Astronomy (miscellaneous)$$c2021$$dQ2
000117195 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b199 / 345 = 0.577$$c2021$$dQ3$$eT2
000117195 593__ $$aMaterials Science (miscellaneous)$$c2021$$dQ2
000117195 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117195 700__ $$aCurlin, M
000117195 700__ $$aJurasin, DD
000117195 700__ $$aVrcek, V
000117195 700__ $$aBarbir, R
000117195 700__ $$aMicek, V
000117195 700__ $$0(orcid)0000-0001-5559-8757$$aFratila, RM
000117195 700__ $$0(orcid)0000-0003-1081-8482$$ade la Fuente, JM
000117195 700__ $$aVrcek, IV
000117195 773__ $$g12 (2021), 665-679$$pBeilstein j. nanotechnol.$$tBEILSTEIN JOURNAL OF NANOTECHNOLOGY$$x2190-4286
000117195 8564_ $$s3785720$$uhttps://zaguan.unizar.es/record/117195/files/texto_completo.pdf$$yVersión publicada
000117195 8564_ $$s1619437$$uhttps://zaguan.unizar.es/record/117195/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117195 909CO $$ooai:zaguan.unizar.es:117195$$particulos$$pdriver
000117195 951__ $$a2023-05-18-15:03:12
000117195 980__ $$aARTICLE