000117208 001__ 117208
000117208 005__ 20240319080951.0
000117208 0247_ $$2doi$$a10.3390/biomedicines10030709
000117208 0248_ $$2sideral$$a128792
000117208 037__ $$aART-2022-128792
000117208 041__ $$aeng
000117208 100__ $$0(orcid)0000-0002-9023-741X$$aSánchez-Marco, J.
000117208 245__ $$aThioredoxin Domain Containing 5 Suppression Elicits Serum Amyloid A-Containing High-Density Lipoproteins
000117208 260__ $$c2022
000117208 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117208 5203_ $$aThioredoxin domain containing 5 (TXNDC5) is a protein disulfide isomerase involved in several diseases related to oxidative stress, energy metabolism and cellular inflammation. In a previous manuscript, a negative association between fatty liver development and hepatic Txndc5 expression was observed. To study the role of TXNDC5 in the liver, we generated Txndc5-deficient mice. The absence of the protein caused an increased metabolic need to gain weight along with a bigger and fatter liver. RNAseq was performed to elucidate the putative mechanisms, showing a substantial liver overexpression of serum amyloid genes (Saa1, Saa2) with no changes in hepatic protein, but discrete plasma augmentation by the gene inactivation. Higher levels of malonyldialdehyde, apolipoprotein A1 and platelet activating factor-aryl esterase activity were also found in serum from Txndc5-deficient mice. However, no difference in the distribution of high-density lipoproteins (HDL)-mayor components and SAA was found between groups, and even the reactive oxygen species decreased in HDL coming from Txndc5-deficient mice. These results confirm the relation of this gene with hepatic steatosis and with a fasting metabolic derive remedying an acute phase response. Likewise, they pose a new role in modulating the nature of HDL particles, and SAA-containing HDL particles are not particularly oxidized. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
000117208 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/DGA-FSE/B16-20R$$9info:eu-repo/grantAgreement/ES/MICINN-ISCIIII-FEDER/PID2019-104915RB-I00
000117208 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117208 590__ $$a4.7$$b2022
000117208 592__ $$a0.897$$b2022
000117208 591__ $$aPHARMACOLOGY & PHARMACY$$b68 / 278 = 0.245$$c2022$$dQ1$$eT1
000117208 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000117208 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b92 / 285 = 0.323$$c2022$$dQ2$$eT1
000117208 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2022$$dQ2
000117208 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b54 / 136 = 0.397$$c2022$$dQ2$$eT2
000117208 594__ $$a3.7$$b2022
000117208 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117208 700__ $$0(orcid)0000-0002-8100-5596$$aMartínez-Beamonte, R.$$uUniversidad de Zaragoza
000117208 700__ $$aDiego, A. de$$uUniversidad de Zaragoza
000117208 700__ $$aHerrero-Continente, T.
000117208 700__ $$0(orcid)0000-0002-8442-8041$$aBarranquero, C.
000117208 700__ $$0(orcid)0000-0003-1197-4276$$aArnal, C.$$uUniversidad de Zaragoza
000117208 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, J.$$uUniversidad de Zaragoza
000117208 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, M. A.$$uUniversidad de Zaragoza
000117208 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza
000117208 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000117208 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000117208 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000117208 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000117208 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000117208 773__ $$g10, 3 (2022), 709 - [16 pp]$$tBiomedicines$$x2227-9059
000117208 8564_ $$s2377156$$uhttps://zaguan.unizar.es/record/117208/files/texto_completo.pdf$$yVersión publicada
000117208 8564_ $$s2821161$$uhttps://zaguan.unizar.es/record/117208/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117208 909CO $$ooai:zaguan.unizar.es:117208$$particulos$$pdriver
000117208 951__ $$a2024-03-18-13:06:24
000117208 980__ $$aARTICLE