000117220 001__ 117220
000117220 005__ 20240319080952.0
000117220 0247_ $$2doi$$a10.3390/pathogens11030377
000117220 0248_ $$2sideral$$a128793
000117220 037__ $$aART-2022-128793
000117220 041__ $$aeng
000117220 100__ $$aMoreno, E.
000117220 245__ $$aPathogenicity and Its Implications in Taxonomy: The Brucella and Ochrobactrum Case
000117220 260__ $$c2022
000117220 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117220 5203_ $$aThe intracellular pathogens of the genus Brucella are phylogenetically close to Ochrobac-trum, a diverse group of free-living bacteria with a few species occasionally infecting medically compromised patients. A group of taxonomists recently included all Ochrobactrum organisms in the genus Brucella based on global genome analyses and alleged equivalences with genera such as Mycobacterium. Here, we demonstrate that such equivalencies are incorrect because they overlook the complexities of pathogenicity. By summarizing Brucella and Ochrobactrum divergences in lifestyle, structure, physiology, population, closed versus open pangenomes, genomic traits, and pathogenicity, we show that when they are adequately understood, they are highly relevant in taxonomy and not unidimensional quantitative characters. Thus, the Ochrobactrum and Brucella differences are not limited to their assignments to different “risk-groups”, a biologically (and hence, taxonomically) oversimplified description that, moreover, does not support ignoring the nomen periculosum rule, as proposed. Since the epidemiology, prophylaxis, diagnosis, and treatment are thoroughly unrelated, merging free-living Ochrobactrum organisms with highly pathogenic Brucella organisms brings evi-dent risks for veterinarians, medical doctors, and public health authorities who confront brucellosis, a significant zoonosis worldwide. Therefore, from taxonomical and practical standpoints, the Brucella and Ochrobactrum genera must be maintained apart. Consequently, we urge researchers, culture collections, and databases to keep their canonical nomenclature. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
000117220 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A13-17R$$9info:eu-repo/grantAgreement/ES/MINECO/PID2019-107601RA-C32
000117220 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117220 590__ $$a3.7$$b2022
000117220 592__ $$a0.807$$b2022
000117220 591__ $$aMICROBIOLOGY$$b62 / 135 = 0.459$$c2022$$dQ2$$eT2
000117220 593__ $$aImmunology and Allergy$$c2022$$dQ2
000117220 593__ $$aImmunology and Microbiology (miscellaneous)$$c2022$$dQ2
000117220 593__ $$aMolecular Biology$$c2022$$dQ2
000117220 593__ $$aMicrobiology (medical)$$c2022$$dQ2
000117220 593__ $$aInfectious Diseases$$c2022$$dQ2
000117220 594__ $$a5.1$$b2022
000117220 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117220 700__ $$aBlasco, J. M.
000117220 700__ $$aLetesson, J. J.
000117220 700__ $$aGorvel, J. P.
000117220 700__ $$aMoriyón, I.
000117220 773__ $$g11, 3 (2022), 377 - [18 pp]$$pPathogens$$tPathogens$$x2076-0817
000117220 8564_ $$s717280$$uhttps://zaguan.unizar.es/record/117220/files/texto_completo.pdf$$yVersión publicada
000117220 8564_ $$s2727546$$uhttps://zaguan.unizar.es/record/117220/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117220 909CO $$ooai:zaguan.unizar.es:117220$$particulos$$pdriver
000117220 951__ $$a2024-03-18-13:11:11
000117220 980__ $$aARTICLE