| Home > Articles > In Vitro Genotoxicity Evaluation of an Antiseptic Formulation Containing Kaolin and Silver Nanoparticles > MARC |
000117230 001__ 117230 000117230 005__ 20240319080954.0 000117230 0247_ $$2doi$$a10.3390/nano12060914 000117230 0248_ $$2sideral$$a128635 000117230 037__ $$aART-2022-128635 000117230 041__ $$aeng 000117230 100__ $$aRodriguez-Garraus, A. 000117230 245__ $$aIn Vitro Genotoxicity Evaluation of an Antiseptic Formulation Containing Kaolin and Silver Nanoparticles 000117230 260__ $$c2022 000117230 5060_ $$aAccess copy available to the general public$$fUnrestricted 000117230 5203_ $$aWorldwide antimicrobial resistance is partly caused by the overuse of antibiotics as growth promoters. Based on the known bactericidal effect of silver, a new material containing silver in a clay base was developed to be used as feed additive. An in vitro genotoxicity evaluation of this silver-kaolin clay formulation was conducted, which included the mouse lymphoma assay in L5178Y TK+/- cells and the micronucleus test in TK6 cells, following the principles of the OECD guidelines 490 and 487, respectively. As a complement, the standard and Fpg-modified comet assays for the evaluation of strand breaks, alkali labile sites and oxidative DNA damage were also performed in TK6 cells. The formulation was tested without metabolic activation after an exposure of 3 h and 24 h; its corresponding release in medium, after the continuous agitation of the silver-kaolin for 24 h was also evaluated. Under the conditions tested, the test compound did not produce gene mutations, chromosomal aberrations or DNA damage (i.e., strand breaks, alkali labile sites or oxidized bases). Considering the results obtained in the present study, the formulation seems to be a promising material to be used as antimicrobial in animal feed. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. 000117230 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000117230 590__ $$a5.3$$b2022 000117230 592__ $$a0.811$$b2022 000117230 591__ $$aPHYSICS, APPLIED$$b39 / 160 = 0.244$$c2022$$dQ1$$eT1 000117230 593__ $$aChemical Engineering (miscellaneous)$$c2022$$dQ1 000117230 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b51 / 107 = 0.477$$c2022$$dQ2$$eT2 000117230 593__ $$aMaterials Science (miscellaneous)$$c2022$$dQ2 000117230 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b58 / 178 = 0.326$$c2022$$dQ2$$eT1 000117230 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b110 / 343 = 0.321$$c2022$$dQ2$$eT1 000117230 594__ $$a7.4$$b2022 000117230 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000117230 700__ $$aAzqueta, A. 000117230 700__ $$0(orcid)0000-0002-4169-0357$$aLaborda, F.$$uUniversidad de Zaragoza 000117230 700__ $$0(orcid)0000-0002-9181-2105$$aGimenez-Ingalaturre, A.$$uUniversidad de Zaragoza 000117230 700__ $$aEzquerra, A. 000117230 700__ $$aLostao, L. 000117230 700__ $$ade Cerain, A. L. 000117230 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000117230 773__ $$g12, 6 (2022), 914 [17 pp]$$pNanomaterials (Basel)$$tNanomaterials$$x2079-4991 000117230 8564_ $$s1165513$$uhttps://zaguan.unizar.es/record/117230/files/texto_completo.pdf$$yVersión publicada 000117230 8564_ $$s2772133$$uhttps://zaguan.unizar.es/record/117230/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000117230 909CO $$ooai:zaguan.unizar.es:117230$$particulos$$pdriver 000117230 951__ $$a2024-03-18-13:27:57 000117230 980__ $$aARTICLE
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