Repositorio Institucional de Documentos

000117231 001__ 117231
000117231 005__ 20240319080954.0
000117231 0247_ $$2doi$$a10.1002/jev2.12193
000117231 0248_ $$2sideral$$a128636
000117231 037__ $$aART-2022-128636
000117231 041__ $$aeng
000117231 100__ $$0(orcid)0000-0001-8762-5457$$aSancho-Albero, M.
000117231 245__ $$aTransfer of photothermal nanoparticles using stem cell derived small extracellular vesicles for in vivo treatment of primary and multinodular tumours; 35257503
000117231 260__ $$c2022
000117231 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117231 5203_ $$aThe main current challenges in oncology are (1) avoiding systemic side effects in therapy, and (2) developing alternative treatment strategies for metastatic tumours. Nanomedicine was assumed to provide answers to these issues, but delivering enough therapeutic nanoparticles (NPs) to tumours still remains a huge challenge in nanomaterials-based treatments. Extracellular vesicles (EVs) play a key role in cell communication processes and can be combined with nanomaterials to improve their targeting capabilities. In this work, we leverage the ability of EVs derived from stem cells to reach tumour areas successfully, being used as delivery vehicles for nanoparticles acting as hyperthermia agents. Once small extracellular vesicles (sEVs) loaded with NIR-sensitive hollow gold NPs reached primary subcutaneous solid tumours, they were irradiated with a NIR laser and almost complete tumour remission was obtained. More interestingly, those sEV vehicles were also able to reach multinodular areas similar to those on advanced metastatic phases, eradicating most tumour growth regions in multiple cancerous nodules located in the pancreas region. © 2022 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles
000117231 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI19-01007$$9info:eu-repo/grantAgreement/ES/ISCIII DTS21-00130
000117231 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000117231 590__ $$a16.0$$b2022
000117231 592__ $$a3.525$$b2022
000117231 591__ $$aCELL BIOLOGY$$b15 / 191 = 0.079$$c2022$$dQ1$$eT1
000117231 593__ $$aHistology$$c2022$$dQ1
000117231 593__ $$aCell Biology$$c2022$$dQ1
000117231 594__ $$a23.9$$b2022
000117231 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117231 700__ $$aEncinas-Giménez, M.$$uUniversidad de Zaragoza
000117231 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, V.$$uUniversidad de Zaragoza
000117231 700__ $$aPérez Rodríguez, E.$$uUniversidad de Zaragoza
000117231 700__ $$0(orcid)0000-0002-2053-9842$$aLuján Lerma, L.$$uUniversidad de Zaragoza
000117231 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, J.$$uUniversidad de Zaragoza
000117231 700__ $$0(orcid)0000-0003-4160-9720$$aMartin-Duque, P.$$uUniversidad de Zaragoza
000117231 7102_ $$11013$$2275$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Estomatología
000117231 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000117231 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000117231 773__ $$g11, 3 (2022), e12193 [15 pp]$$pJ. extracell. vesicles$$tJournal of Extracellular Vesicles$$x2001-3078
000117231 8564_ $$s13129433$$uhttps://zaguan.unizar.es/record/117231/files/texto_completo.pdf$$yVersión publicada
000117231 8564_ $$s2273267$$uhttps://zaguan.unizar.es/record/117231/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117231 909CO $$ooai:zaguan.unizar.es:117231$$particulos$$pdriver
000117231 951__ $$a2024-03-18-13:28:05
000117231 980__ $$aARTICLE

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