117231 20240319080954.0 doi 10.1002/jev2.12193 sideral 128636 ART-2022-128636 eng Sancho-Albero, M. (orcid)0000-0001-8762-5457 Transfer of photothermal nanoparticles using stem cell derived small extracellular vesicles for in vivo treatment of primary and multinodular tumours; 35257503 2022 Access copy available to the general public Unrestricted The main current challenges in oncology are (1) avoiding systemic side effects in therapy, and (2) developing alternative treatment strategies for metastatic tumours. Nanomedicine was assumed to provide answers to these issues, but delivering enough therapeutic nanoparticles (NPs) to tumours still remains a huge challenge in nanomaterials-based treatments. Extracellular vesicles (EVs) play a key role in cell communication processes and can be combined with nanomaterials to improve their targeting capabilities. In this work, we leverage the ability of EVs derived from stem cells to reach tumour areas successfully, being used as delivery vehicles for nanoparticles acting as hyperthermia agents. Once small extracellular vesicles (sEVs) loaded with NIR-sensitive hollow gold NPs reached primary subcutaneous solid tumours, they were irradiated with a NIR laser and almost complete tumour remission was obtained. More interestingly, those sEV vehicles were also able to reach multinodular areas similar to those on advanced metastatic phases, eradicating most tumour growth regions in multiple cancerous nodules located in the pancreas region. © 2022 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles info:eu-repo/grantAgreement/ES/ISCIII DTS21-00130 info:eu-repo/grantAgreement/ES/ISCIII/PI19-01007 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 16.0 2022 CELL BIOLOGY 15 / 191 = 0.079 2022 Q1 T1 3.525 2022 Histology 2022 Q1 Cell Biology 2022 Q1 23.9 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Encinas-Giménez, M. Universidad de Zaragoza Sebastián, V. Universidad de Zaragoza (orcid)0000-0002-6873-5244 Pérez Rodríguez, E. Universidad de Zaragoza Luján Lerma, L. Universidad de Zaragoza (orcid)0000-0002-2053-9842 Santamaría, J. Universidad de Zaragoza (orcid)0000-0002-8701-9745 Martin-Duque, P. Universidad de Zaragoza (orcid)0000-0003-4160-9720 1013 275 Universidad de Zaragoza Dpto. Cirugía Área Estomatología 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 11, 3 (2022), e12193 [15 pp] J. extracell. vesicles Journal of Extracellular Vesicles 2001-3078 13129433 http://zaguan.unizar.es/record/117231/files/texto_completo.pdf Versión publicada 2273267 http://zaguan.unizar.es/record/117231/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:117231 articulos driver 2024-03-18-13:28:05 ARTICLE