000117243 001__ 117243
000117243 005__ 20240319080955.0
000117243 0247_ $$2doi$$a10.3390/antiox11050828
000117243 0248_ $$2sideral$$a128957
000117243 037__ $$aART-2022-128957
000117243 041__ $$aeng
000117243 100__ $$0(orcid)0009-0001-5345-6947$$aQuero, J.$$uUniversidad de Zaragoza
000117243 245__ $$aUnveiling the Antioxidant Therapeutic Functionality of Sustainable Olive Pomace Active Ingredients
000117243 260__ $$c2022
000117243 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117243 5203_ $$aOlive pomace (OP) is the main residue that results from olive oil production. OP is rich in bioactive compounds, including polyphenols, so its use in the treatments of diseases related to oxidative stress, such as cancer, could be considered. The present work aimed to study the biological properties of different OP extracts, obtained by ohmic heating-assisted extraction and conventional heating, using water and 50% ethanol, in the treatment and prevention of colorectal cancer through Caco-2 cell models. Additionally, an in-silico analysis was performed to identify the phenolic intestinal absorption and Caco-2 permeability. The extracts were chemically characterized, and it was found that the Ohmic-hydroethanolic (OH-EtOH) extract had the highest antiproliferative effect, probably due to its higher content of phenolic compounds. The OH-EtOH induced potential modifications in the mitochondrial membrane and led to apoptosis by cell cycle arrest in the G1/S phases with activation of p53 and caspase 3 proteins. In addition, this extract protected the intestine against oxidative stress (ROS) caused by H2 O2. Therefore, the bioactive compounds present in OP and recovered by applying a green technology such as ohmic-heating, show promising potential to be used in food, nutraceutical, and biomedical applications, reducing this waste and facilitating the circular economy. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
000117243 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/B16-20R$$9info:eu-repo/grantAgreement/ES/ISCIII-CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/MCIU/RED2018-102471-T$$9info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123
000117243 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117243 590__ $$a7.0$$b2022
000117243 592__ $$a1.084$$b2022
000117243 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b46 / 285 = 0.161$$c2022$$dQ1$$eT1
000117243 593__ $$aBiochemistry$$c2022$$dQ1
000117243 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b13 / 142 = 0.092$$c2022$$dQ1$$eT1
000117243 593__ $$aClinical Biochemistry$$c2022$$dQ1
000117243 591__ $$aCHEMISTRY, MEDICINAL$$b6 / 60 = 0.1$$c2022$$dQ1$$eT1
000117243 593__ $$aFood Science$$c2022$$dQ1
000117243 593__ $$aPhysiology$$c2022$$dQ1
000117243 593__ $$aMolecular Biology$$c2022$$dQ2
000117243 593__ $$aCell Biology$$c2022$$dQ2
000117243 594__ $$a8.8$$b2022
000117243 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117243 700__ $$aBallesteros, L. F.
000117243 700__ $$aFerreira-Santos, P.
000117243 700__ $$aVelderrain-Rodriguez, G.
000117243 700__ $$aRocha, C. M. R.
000117243 700__ $$aPereira, R. N.
000117243 700__ $$aTeixeira, J. A.
000117243 700__ $$aMartin-Belloso, O.
000117243 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza
000117243 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez-Yoldi, M. J.$$uUniversidad de Zaragoza
000117243 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000117243 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000117243 773__ $$g11, 5 (2022), 828 [22 pp]$$pAntioxidants$$tAntioxidants$$x2076-3921
000117243 8564_ $$s4143550$$uhttps://zaguan.unizar.es/record/117243/files/texto_completo.pdf$$yVersión publicada
000117243 8564_ $$s2752998$$uhttps://zaguan.unizar.es/record/117243/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117243 909CO $$ooai:zaguan.unizar.es:117243$$particulos$$pdriver
000117243 951__ $$a2024-03-18-13:34:29
000117243 980__ $$aARTICLE