000117253 001__ 117253 000117253 005__ 20240319081001.0 000117253 0247_ $$2doi$$a10.3390/biology11050667 000117253 0248_ $$2sideral$$a128693 000117253 037__ $$aART-2022-128693 000117253 041__ $$aeng 000117253 100__ $$aHerbst, Allen 000117253 245__ $$aSusceptibility of Beavers to Chronic Wasting Disease 000117253 260__ $$c2022 000117253 5060_ $$aAccess copy available to the general public$$fUnrestricted 000117253 5203_ $$aChronic wasting disease (CWD) is a contagious, fatal, neurodegenerative prion disease of cervids. The expanding geographical range and rising prevalence of CWD are increasing the risk of pathogen transfer and spillover of CWD to non-cervid sympatric species. As beavers have close contact with environmental and food sources of CWD infectivity, we hypothesized that they may be susceptible to CWD prions. We evaluated the susceptibility of beavers to prion diseases by challenging transgenic mice expressing beaver prion protein (tgBeaver) with five strains of CWD, four isolates of rodent-adapted prions and one strain of Creutzfeldt–Jakob disease. All CWD strains transmitted to the tgBeaver mice, with attack rates highest from moose CWD and the 116AG and H95+ strains of deer CWD. Mouse-, rat-, and especially hamster-adapted prions were also transmitted with complete attack rates and short incubation periods. We conclude that the beaver prion protein is an excellent substrate for sustaining prion replication and that beavers are at risk for CWD pathogen transfer and spillover. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. 000117253 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000117253 590__ $$a4.2$$b2022 000117253 592__ $$a0.779$$b2022 000117253 591__ $$aBIOLOGY$$b25 / 92 = 0.272$$c2022$$dQ2$$eT1 000117253 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2022$$dQ1 000117253 593__ $$aImmunology and Microbiology (miscellaneous)$$c2022$$dQ2 000117253 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2022$$dQ2 000117253 594__ $$a4.0$$b2022 000117253 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000117253 700__ $$aWohlgemuth, Serene 000117253 700__ $$aYang, Jing 000117253 700__ $$aCastle, Andrew R. 000117253 700__ $$aMartínez Moreno, Diana 000117253 700__ $$0(orcid)0000-0001-9075-2764$$aOtero, Alicia$$uUniversidad de Zaragoza 000117253 700__ $$aAiken, Judd M. 000117253 700__ $$aWestaway, David 000117253 700__ $$aMcKenzie, Debbie 000117253 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000117253 773__ $$g11, 5 (2022), 667 [11 pp]$$tBiology$$x2079-7737 000117253 8564_ $$s2226606$$uhttps://zaguan.unizar.es/record/117253/files/texto_completo.pdf$$yVersión publicada 000117253 8564_ $$s2681878$$uhttps://zaguan.unizar.es/record/117253/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000117253 909CO $$ooai:zaguan.unizar.es:117253$$particulos$$pdriver 000117253 951__ $$a2024-03-18-14:09:36 000117253 980__ $$aARTICLE