117253 20240319081001.0 doi 10.3390/biology11050667 sideral 128693 ART-2022-128693 eng Herbst, Allen Susceptibility of Beavers to Chronic Wasting Disease 2022 Access copy available to the general public Unrestricted Chronic wasting disease (CWD) is a contagious, fatal, neurodegenerative prion disease of cervids. The expanding geographical range and rising prevalence of CWD are increasing the risk of pathogen transfer and spillover of CWD to non-cervid sympatric species. As beavers have close contact with environmental and food sources of CWD infectivity, we hypothesized that they may be susceptible to CWD prions. We evaluated the susceptibility of beavers to prion diseases by challenging transgenic mice expressing beaver prion protein (tgBeaver) with five strains of CWD, four isolates of rodent-adapted prions and one strain of Creutzfeldt–Jakob disease. All CWD strains transmitted to the tgBeaver mice, with attack rates highest from moose CWD and the 116AG and H95+ strains of deer CWD. Mouse-, rat-, and especially hamster-adapted prions were also transmitted with complete attack rates and short incubation periods. We conclude that the beaver prion protein is an excellent substrate for sustaining prion replication and that beavers are at risk for CWD pathogen transfer and spillover. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.2 2022 BIOLOGY 25 / 92 = 0.272 2022 Q2 T1 0.779 2022 Agricultural and Biological Sciences (miscellaneous) 2022 Q1 Immunology and Microbiology (miscellaneous) 2022 Q2 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2022 Q2 4.0 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Wohlgemuth, Serene Yang, Jing Castle, Andrew R. Martínez Moreno, Diana Otero, Alicia Universidad de Zaragoza (orcid)0000-0001-9075-2764 Aiken, Judd M. Westaway, David McKenzie, Debbie 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 11, 5 (2022), 667 [11 pp] Biology 2079-7737 2226606 http://zaguan.unizar.es/record/117253/files/texto_completo.pdf Versión publicada 2681878 http://zaguan.unizar.es/record/117253/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:117253 articulos driver 2024-03-18-14:09:36 ARTICLE