000117270 001__ 117270
000117270 005__ 20240319081025.0
000117270 0247_ $$2doi$$a10.3389/ti.2022.10263
000117270 0248_ $$2sideral$$a128611
000117270 037__ $$aART-2022-128611
000117270 041__ $$aeng
000117270 100__ $$0(orcid)0000-0002-7119-2244$$aSerrano, M. Trinidad$$uUniversidad de Zaragoza
000117270 245__ $$aMortality and Causes of Death After Liver Transplantation: Analysis of Sex Differences in a Large Nationwide Cohort
000117270 260__ $$c2022
000117270 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117270 5203_ $$aIn the last few years, several studies have analyzed sex and gender differences in liver transplantation (LT), but none have performed a disaggregated analysis of both mortality and causes of death. Data from 15,998 patients, 11,914 (74.5%) males and 4,069 (25.5%) females, transplanted between 2000 and 2016 were obtained from the Liver Transplantation Spanish Registry. Survival analysis was applied to explore recipient sex as a risk factor for death. The causes of death at different follow-up duration were disaggregated by recipient sex for analysis. Short-term survival was higher in males, whereas long-term survival was higher in females. Survival at 1, 5 and 10 years post-transplant was 87.43%, 73.83%, and 61.23%, respectively, in males and 86.28%, 74.19%, and 65.10%, respectively, in females (p = 0.05). Post-LT mortality related to previous liver disease also presented sex differences. Males had 37% increased overall mortality from acute liver failure (p = 0.035) and 37% from HCV-negative cirrhosis (p < 0.001). Females had approximately 16% increased mortality when the liver disease was HCV-positive cirrhosis (p = 0.003). Regarding causes of death, non-malignancy HCV+ recurrence (6.3% vs. 3.9% of patients; p < 0.001), was more frequently reported in females. By contrast, death because of malignancy recurrence (3.9% vs. 2.2% of patients; p = 0.003) and de novo malignancy (4.8% vs. 2.5% of patients; p < 0.001) were significantly more frequent in male recipients. Cardiovascular disease, renal failure, and surgical complications were similar in both. In summary, male patients have lower short-term mortality than females but higher long-term and overall mortality. In addition, the post-LT mortality risk related to previous liver disease and the causes of mortality differ between males and females.
000117270 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/RIS3-LMP223-18
000117270 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117270 590__ $$a3.1$$b2022
000117270 592__ $$a0.807$$b2022
000117270 591__ $$aSURGERY$$b50 / 213 = 0.235$$c2022$$dQ1$$eT1
000117270 593__ $$aTransplantation$$c2022$$dQ2
000117270 591__ $$aTRANSPLANTATION$$b14 / 26 = 0.538$$c2022$$dQ3$$eT2
000117270 594__ $$a4.5$$b2022
000117270 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117270 700__ $$aSabroso, Sergio
000117270 700__ $$0(orcid)0000-0002-3007-302X$$aEsteban, Luis M.
000117270 700__ $$aBerenguer, Marina
000117270 700__ $$aFondevila, Constantino
000117270 700__ $$0(orcid)0000-0003-4672-8083$$aLorente, Sara$$uUniversidad de Zaragoza
000117270 700__ $$aCortés, Luis$$uUniversidad de Zaragoza
000117270 700__ $$aSanchez-Antolin, Gloria
000117270 700__ $$aNuño, Javier
000117270 700__ $$aDe la Rosa, Gloria
000117270 700__ $$aSalcedo, Magdalena
000117270 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000117270 773__ $$g35 (2022), 10263 [12 pp.]$$pTranspl. int.$$tTRANSPLANT INTERNATIONAL$$x0934-0874
000117270 8564_ $$s1724308$$uhttps://zaguan.unizar.es/record/117270/files/texto_completo.pdf$$yVersión publicada
000117270 8564_ $$s2396680$$uhttps://zaguan.unizar.es/record/117270/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117270 909CO $$ooai:zaguan.unizar.es:117270$$particulos$$pdriver
000117270 951__ $$a2024-03-18-16:37:13
000117270 980__ $$aARTICLE