117270 20240319081025.0 doi 10.3389/ti.2022.10263 sideral 128611 ART-2022-128611 eng Serrano, M. Trinidad Universidad de Zaragoza (orcid)0000-0002-7119-2244 Mortality and Causes of Death After Liver Transplantation: Analysis of Sex Differences in a Large Nationwide Cohort 2022 Access copy available to the general public Unrestricted In the last few years, several studies have analyzed sex and gender differences in liver transplantation (LT), but none have performed a disaggregated analysis of both mortality and causes of death. Data from 15,998 patients, 11,914 (74.5%) males and 4,069 (25.5%) females, transplanted between 2000 and 2016 were obtained from the Liver Transplantation Spanish Registry. Survival analysis was applied to explore recipient sex as a risk factor for death. The causes of death at different follow-up duration were disaggregated by recipient sex for analysis. Short-term survival was higher in males, whereas long-term survival was higher in females. Survival at 1, 5 and 10 years post-transplant was 87.43%, 73.83%, and 61.23%, respectively, in males and 86.28%, 74.19%, and 65.10%, respectively, in females (p = 0.05). Post-LT mortality related to previous liver disease also presented sex differences. Males had 37% increased overall mortality from acute liver failure (p = 0.035) and 37% from HCV-negative cirrhosis (p < 0.001). Females had approximately 16% increased mortality when the liver disease was HCV-positive cirrhosis (p = 0.003). Regarding causes of death, non-malignancy HCV+ recurrence (6.3% vs. 3.9% of patients; p < 0.001), was more frequently reported in females. By contrast, death because of malignancy recurrence (3.9% vs. 2.2% of patients; p = 0.003) and de novo malignancy (4.8% vs. 2.5% of patients; p < 0.001) were significantly more frequent in male recipients. Cardiovascular disease, renal failure, and surgical complications were similar in both. In summary, male patients have lower short-term mortality than females but higher long-term and overall mortality. In addition, the post-LT mortality risk related to previous liver disease and the causes of mortality differ between males and females. info:eu-repo/grantAgreement/ES/DGA-FSE/RIS3-LMP223-18 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.1 2022 SURGERY 50 / 213 = 0.235 2022 Q1 T1 TRANSPLANTATION 14 / 26 = 0.538 2022 Q3 T2 0.807 2022 Transplantation 2022 Q2 4.5 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sabroso, Sergio Esteban, Luis M. (orcid)0000-0002-3007-302X Berenguer, Marina Fondevila, Constantino Lorente, Sara Universidad de Zaragoza (orcid)0000-0003-4672-8083 Cortés, Luis Universidad de Zaragoza Sanchez-Antolin, Gloria Nuño, Javier De la Rosa, Gloria Salcedo, Magdalena 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 35 (2022), 10263 [12 pp.] Transpl. int. TRANSPLANT INTERNATIONAL 0934-0874 1724308 http://zaguan.unizar.es/record/117270/files/texto_completo.pdf Versión publicada 2396680 http://zaguan.unizar.es/record/117270/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:117270 articulos driver 2024-03-18-16:37:13 ARTICLE