000117280 001__ 117280 000117280 005__ 20240319080959.0 000117280 0247_ $$2doi$$a10.1177/20417314221091682 000117280 0248_ $$2sideral$$a128755 000117280 037__ $$aART-2022-128755 000117280 041__ $$aeng 000117280 100__ $$0(orcid)0000-0001-7062-9099$$aGarcía Gareta, E.$$uUniversidad de Zaragoza 000117280 245__ $$aDecellularization of tumours: A new frontier in tissue engineering 000117280 260__ $$c2022 000117280 5060_ $$aAccess copy available to the general public$$fUnrestricted 000117280 5203_ $$aCancer is one of the leading causes of death worldwide. The tumour extracellular matrix (ECM) has unique features in terms of composition and mechanical properties, resulting in a structurally and chemically different ECM to that of native, healthy tissues. This paper reviews to date the efforts into decellularization of tumours, which in the authors’ view represents a new frontier in the ever evolving field of tumour tissue engineering. An overview of the ECM and its importance in cancer is given, ending with examples of research using decellularized tumours, which has already indicated potential therapeutic targets, unravelled malignancy mechanisms or response to chemotherapy agents. The review highlights that more research is needed in this area, which can answer important questions related to tumour formation and progression to ultimately identify new and effective therapeutic targets. Within the near-future of personalized medicine, this research can create patient-specific tumour models and therapeutic regimes. 000117280 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-113819RB-I00$$9info:eu-repo/grantAgreement/EC/H2020/101018587/EU/Individual and Collective Migration of the Immune Cellular System/ICoMICS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101018587-ICoMICS$$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-094494-B-C21 000117280 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/ 000117280 590__ $$a8.2$$b2022 000117280 592__ $$a0.991$$b2022 000117280 591__ $$aCELL & TISSUE ENGINEERING$$b3 / 29 = 0.103$$c2022$$dQ1$$eT1 000117280 593__ $$aBiomedical Engineering$$c2022$$dQ1 000117280 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1 000117280 593__ $$aBiomaterials$$c2022$$dQ2 000117280 594__ $$a9.9$$b2022 000117280 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion 000117280 700__ $$0(orcid)0000-0002-2901-4188$$aPérez, M. Á.$$uUniversidad de Zaragoza 000117280 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía Aznar, J. M.$$uUniversidad de Zaragoza 000117280 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est. 000117280 7102_ $$15001$$2065$$aUniversidad de Zaragoza$$bDpto. Ciencia Tecnol.Mater.Fl.$$cÁrea Cienc.Mater. Ingen.Metal. 000117280 773__ $$g13 (2022), [16 pp.]$$pJournal of Tissue Engineering$$tJournal of Tissue Engineering$$x2041-7314 000117280 8564_ $$s995085$$uhttps://zaguan.unizar.es/record/117280/files/texto_completo.pdf$$yVersión publicada 000117280 8564_ $$s2459562$$uhttps://zaguan.unizar.es/record/117280/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000117280 909CO $$ooai:zaguan.unizar.es:117280$$particulos$$pdriver 000117280 951__ $$a2024-03-18-13:59:52 000117280 980__ $$aARTICLE