117280 20240319080959.0 doi 10.1177/20417314221091682 sideral 128755 ART-2022-128755 eng García Gareta, E. Universidad de Zaragoza (orcid)0000-0001-7062-9099 Decellularization of tumours: A new frontier in tissue engineering 2022 Access copy available to the general public Unrestricted Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix (ECM) has unique features in terms of composition and mechanical properties, resulting in a structurally and chemically different ECM to that of native, healthy tissues. This paper reviews to date the efforts into decellularization of tumours, which in the authors’ view represents a new frontier in the ever evolving field of tumour tissue engineering. An overview of the ECM and its importance in cancer is given, ending with examples of research using decellularized tumours, which has already indicated potential therapeutic targets, unravelled malignancy mechanisms or response to chemotherapy agents. The review highlights that more research is needed in this area, which can answer important questions related to tumour formation and progression to ultimately identify new and effective therapeutic targets. Within the near-future of personalized medicine, this research can create patient-specific tumour models and therapeutic regimes. info:eu-repo/grantAgreement/ES/AEI/PID2020-113819RB-I00 info:eu-repo/grantAgreement/EC/H2020/101018587/EU/Individual and Collective Migration of the Immune Cellular System/ICoMICS This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101018587-ICoMICS info:eu-repo/grantAgreement/ES/MICINN/RTI2018-094494-B-C21 info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 8.2 2022 CELL & TISSUE ENGINEERING 3 / 29 = 0.103 2022 Q1 T1 0.991 2022 Biomedical Engineering 2022 Q1 Medicine (miscellaneous) 2022 Q1 Biomaterials 2022 Q2 9.9 2022 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Pérez, M. Á. Universidad de Zaragoza (orcid)0000-0002-2901-4188 García Aznar, J. M. Universidad de Zaragoza (orcid)0000-0002-9864-7683 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 5001 065 Universidad de Zaragoza Dpto. Ciencia Tecnol.Mater.Fl. Área Cienc.Mater. Ingen.Metal. 13 (2022), [16 pp.] Journal of Tissue Engineering Journal of Tissue Engineering 2041-7314 995085 http://zaguan.unizar.es/record/117280/files/texto_completo.pdf Versión publicada 2459562 http://zaguan.unizar.es/record/117280/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:117280 articulos driver 2024-03-18-13:59:52 ARTICLE