000117359 001__ 117359
000117359 005__ 20230519145534.0
000117359 0247_ $$2doi$$a10.1038/s41398-021-01755-3
000117359 0248_ $$2sideral$$a127003
000117359 037__ $$aART-2021-127003
000117359 041__ $$aeng
000117359 100__ $$aCaso J.R.
000117359 245__ $$aGut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder
000117359 260__ $$c2021
000117359 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117359 5203_ $$aAlthough alterations in the gut microbiota have been linked to the pathophysiology of major depressive disorder (MDD), including through effects on the immune response, our understanding is deficient about the straight connection patterns among microbiota and MDD in patients. Male and female MDD patients were recruited: 46 patients with a current active MDD (a-MDD) and 22 in remission or with only mild symptoms (r-MDD). Forty-five healthy controls (HC) were also recruited. Psychopathological states were assessed, and fecal and blood samples were collected. Results indicated that the inducible nitric oxide synthase expression was higher in MDD patients compared with HC and the oxidative stress levels were greater in the a-MDD group. Furthermore, the lipopolysaccharide (an indirect marker of bacterial translocation) was higher in a-MDD patients compared with the other groups. Fecal samples did not cluster according to the presence or the absence of MDD. There were bacterial genera whose relative abundance was altered in MDD: Bilophila (2-fold) and Alistipes (1.5-fold) were higher, while Anaerostipes (1.5-fold) and Dialister (15-fold) were lower in MDD patients compared with HC. Patients with a-MDD presented higher relative abundance of Alistipes and Anaerostipes (1.5-fold) and a complete depletion of Dialister compared with HC. Patients with r-MDD presented higher abundance of Bilophila (2.5-fold) compared with HC. Thus, the abundance of bacterial genera and some immune pathways, both with potential implications in the pathophysiology of depression, appear to be altered in MDD, with the most noticeable changes occurring in patients with the worse clinical condition, the a-MDD group. © 2021, The Author(s).
000117359 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI13-01102$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-109033RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/SAF2016-75500-R
000117359 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117359 590__ $$a7.989$$b2021
000117359 592__ $$a2.076$$b2021
000117359 594__ $$a8.5$$b2021
000117359 591__ $$aPSYCHIATRY$$b24 / 157 = 0.153$$c2021$$dQ1$$eT1
000117359 593__ $$aCellular and Molecular Neuroscience$$c2021$$dQ1
000117359 593__ $$aBiological Psychiatry$$c2021$$dQ1
000117359 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117359 700__ $$aMacDowell K.S.
000117359 700__ $$aGonzález-Pinto A.
000117359 700__ $$aGarcía S.
000117359 700__ $$ade Diego-Adeliño J.
000117359 700__ $$aCarceller-Sindreu M.
000117359 700__ $$aSarramea F.
000117359 700__ $$aCaballero-Villarraso J.
000117359 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García P.$$uUniversidad de Zaragoza
000117359 700__ $$0(orcid)0000-0003-2284-7862$$aDe la Cámara C.$$uUniversidad de Zaragoza
000117359 700__ $$aAgüera L.
000117359 700__ $$aGómez-Lus M.L.
000117359 700__ $$aAlba C.
000117359 700__ $$aRodríguez J.M.
000117359 700__ $$aLeza J.C.
000117359 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000117359 773__ $$g11 (2021), 645 [10 pp]$$pTransl Psychiatr$$tTranslational Psychiatry$$x2158-3188
000117359 8564_ $$s1724048$$uhttps://zaguan.unizar.es/record/117359/files/texto_completo.pdf$$yVersión publicada
000117359 8564_ $$s3028288$$uhttps://zaguan.unizar.es/record/117359/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117359 909CO $$ooai:zaguan.unizar.es:117359$$particulos$$pdriver
000117359 951__ $$a2023-05-18-15:33:53
000117359 980__ $$aARTICLE