117359 20230519145534.0 doi 10.1038/s41398-021-01755-3 sideral 127003 ART-2021-127003 eng Caso J.R. Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder 2021 Access copy available to the general public Unrestricted Although alterations in the gut microbiota have been linked to the pathophysiology of major depressive disorder (MDD), including through effects on the immune response, our understanding is deficient about the straight connection patterns among microbiota and MDD in patients. Male and female MDD patients were recruited: 46 patients with a current active MDD (a-MDD) and 22 in remission or with only mild symptoms (r-MDD). Forty-five healthy controls (HC) were also recruited. Psychopathological states were assessed, and fecal and blood samples were collected. Results indicated that the inducible nitric oxide synthase expression was higher in MDD patients compared with HC and the oxidative stress levels were greater in the a-MDD group. Furthermore, the lipopolysaccharide (an indirect marker of bacterial translocation) was higher in a-MDD patients compared with the other groups. Fecal samples did not cluster according to the presence or the absence of MDD. There were bacterial genera whose relative abundance was altered in MDD: Bilophila (2-fold) and Alistipes (1.5-fold) were higher, while Anaerostipes (1.5-fold) and Dialister (15-fold) were lower in MDD patients compared with HC. Patients with a-MDD presented higher relative abundance of Alistipes and Anaerostipes (1.5-fold) and a complete depletion of Dialister compared with HC. Patients with r-MDD presented higher abundance of Bilophila (2.5-fold) compared with HC. Thus, the abundance of bacterial genera and some immune pathways, both with potential implications in the pathophysiology of depression, appear to be altered in MDD, with the most noticeable changes occurring in patients with the worse clinical condition, the a-MDD group. © 2021, The Author(s). info:eu-repo/grantAgreement/ES/FIS/PI13-01102 info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-109033RB-I00 info:eu-repo/grantAgreement/ES/MICINN/SAF2016-75500-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 7.989 2021 PSYCHIATRY 24 / 157 = 0.153 2021 Q1 T1 2.076 2021 Cellular and Molecular Neuroscience 2021 Q1 Biological Psychiatry 2021 Q1 8.5 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion MacDowell K.S. González-Pinto A. García S. de Diego-Adeliño J. Carceller-Sindreu M. Sarramea F. Caballero-Villarraso J. Gracia-García P. Universidad de Zaragoza (orcid)0000-0001-9822-6312 De la Cámara C. Universidad de Zaragoza (orcid)0000-0003-2284-7862 Agüera L. Gómez-Lus M.L. Alba C. Rodríguez J.M. Leza J.C. 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 11 (2021), 645 [10 pp] Transl Psychiatr Translational Psychiatry 2158-3188 1724048 http://zaguan.unizar.es/record/117359/files/texto_completo.pdf Versión publicada 3028288 http://zaguan.unizar.es/record/117359/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:117359 articulos driver 2023-05-18-15:33:53 ARTICLE