000117370 001__ 117370
000117370 005__ 20230519145535.0
000117370 0247_ $$2doi$$a10.3390/nu13124488
000117370 0248_ $$2sideral$$a127014
000117370 037__ $$aART-2021-127014
000117370 041__ $$aeng
000117370 100__ $$aPires L.V.
000117370 245__ $$aThe vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP study
000117370 260__ $$c2021
000117370 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117370 5203_ $$aObesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4–12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired t-test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = -0.274, p = 0.032; B = -0.219, p = 0.019; B = -0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations (p < 0.05 for all) over time. These results suggest that changes in IR seem to be associated with an effect on 25(OH)D levels during puberty, especially in children with overweight. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
000117370 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043$$9info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-01425$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI20-00563$$9info:eu-repo/grantAgreement/ES/ISCIII/i-PFIS-IFI17-00048$$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD12-0026-0015$$9info:eu-repo/grantAgreement/ES/MINECO/FJCI-2017-34967
000117370 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117370 590__ $$a6.706$$b2021
000117370 592__ $$a1.287$$b2021
000117370 594__ $$a7.9$$b2021
000117370 591__ $$aNUTRITION & DIETETICS$$b15 / 90 = 0.167$$c2021$$dQ1$$eT1
000117370 593__ $$aNutrition and Dietetics$$c2021$$dQ1
000117370 593__ $$aFood Science$$c2021$$dQ1
000117370 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117370 700__ $$0(orcid)0000-0003-2005-8229$$aGonzález-Gil E.M.$$uUniversidad de Zaragoza
000117370 700__ $$aAnguita-Ruiz A.
000117370 700__ $$0(orcid)0000-0002-0902-387X$$aBueno G.$$uUniversidad de Zaragoza
000117370 700__ $$aGil-Campos M.
000117370 700__ $$aVázquez-Cobela R.
000117370 700__ $$aPérez-Ferreirós A.
000117370 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno L.A.$$uUniversidad de Zaragoza
000117370 700__ $$aGil Á.
000117370 700__ $$aLeis R.
000117370 700__ $$aAguilera C.M.
000117370 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000117370 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000117370 773__ $$g13, 12 (2021), 4488 [14 pp]$$pNutrients$$tNutrients$$x2072-6643
000117370 8564_ $$s339432$$uhttps://zaguan.unizar.es/record/117370/files/texto_completo.pdf$$yVersión publicada
000117370 8564_ $$s2767887$$uhttps://zaguan.unizar.es/record/117370/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117370 909CO $$ooai:zaguan.unizar.es:117370$$particulos$$pdriver
000117370 951__ $$a2023-05-18-15:35:05
000117370 980__ $$aARTICLE