117384 20230519145548.0 doi 10.1016/j.bcp.2021.114655 sideral 127078 ART-2021-127078 eng Serrano-del Valle A. Future prospects for mitosis-targeted antitumor therapies 2021 Access copy available to the general public Unrestricted Dysregulation of cell cycle progression is a hallmark of cancer cells. In recent years, efforts have been devoted to the development of new therapies that target proteins involved in cell cycle regulation and mitosis. Novel targeted antimitotic drugs include inhibitors of aurora kinase family, polo-like kinase 1, Mps1, Eg5, CENP-5 and the APC/cyclosome complex. While certain new inhibitors reached the clinical trial stage, most were discontinued due to negative results. However, these therapies should not be readily dismissed. Based on recent advances concerning their mechanisms of action, new strategies could be devised to increase their efficacy and promote further clinical trials. Here we discuss three main lines of action to empower these therapeutic approaches: increasing cell death signals during mitotic arrest, targeting senescent cells and facilitating antitumor immune response through immunogenic cell death (ICD). © 2021 The Author(s) info:eu-repo/grantAgreement/ES/MINECO/SAF2016-76338-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.1 2021 PHARMACOLOGY & PHARMACY 46 / 279 = 0.165 2021 Q1 T1 1.24 2021 Pharmacology 2021 Q1 Biochemistry 2021 Q1 9.3 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reina-Ortiz C. Benedi A. Universidad de Zaragoza Anel A. Universidad de Zaragoza (orcid)0000-0002-5175-8394 Naval J. Universidad de Zaragoza (orcid)0000-0003-2156-8378 Marzo I. Universidad de Zaragoza (orcid)0000-0002-2315-9079 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 190 (2021), 114655 [13 pp] Biochem. pharmacol. Biochemical Pharmacology 0006-2952 4109241 http://zaguan.unizar.es/record/117384/files/texto_completo.pdf Versión publicada 2631197 http://zaguan.unizar.es/record/117384/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:117384 articulos driver 2023-05-18-15:46:56 ARTICLE