000117397 001__ 117397
000117397 005__ 20230519145606.0
000117397 0247_ $$2doi$$a10.1002/chem.202100707
000117397 0248_ $$2sideral$$a127233
000117397 037__ $$aART-2021-127233
000117397 041__ $$aeng
000117397 100__ $$0(orcid)0000-0001-5201-0874$$aRedrado M.
000117397 245__ $$aMultifunctional heterometallic Iriii-Aui probes as promising anticancer and antiangiogenic agents
000117397 260__ $$c2021
000117397 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117397 5203_ $$aA new class of emissive cyclometallated IrIII-AuI complexes with a bis(diphenylphosphino) methanide bridging ligand was successfully synthesised from the diphosphino complex [Ir(N^C)2(dppm)]+ (1). The different gold ancillary ligand, a triphenylphosphine (2), a chloride (3) or a thiocytosine (4) did not reveal any significant effect on the photophysical properties, which are mainly due to metal-to-ligand charge-transfer (3MLCT) transitions based on IrIII. However, the AuI fragment, along with the ancillary ligand, seemed crucial for the bioactivity in A549 lung carcinoma cells versus endothelial cells. Both cell types display variable sensitivities to the complexes (IC50=0.6–3.5 µM). The apoptotic pathway is activated in all cases, and paraptotic cell death seems to take place at initial stages in A549 cells. Species 2–4 showed at least dual lysosomal and mitochondrial biodistribution in A549 cells, with an initial lysosomal localisation and a possible trafficking process between both organelles with time. The bimetallic IrIII-AuI complexes disrupted the mitochondrial transmembrane potential in A549 cells and increased reactive oxygen species (ROS) generation and thioredoxin reductase (TrxR) inhibition in comparison with that displayed by the monometallic complex 1. Angiogenic activity assays performed in endothelial cells revealed the promising antimetastatic potential of 1, 2 and 4. © 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
000117397 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B04-20R$$9info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS-PI16-02112$$9info:eu-repo/grantAgreement/ES/MCIU/PID2019-104379RB-C21$$9info:eu-repo/grantAgreement/ES/MCIU/RED2018-102471-T$$9info:eu-repo/grantAgreement/ES/MICINN/RYC-2018-025872-I
000117397 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117397 590__ $$a5.02$$b2021
000117397 592__ $$a1.343$$b2021
000117397 594__ $$a9.1$$b2021
000117397 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b64 / 180 = 0.356$$c2021$$dQ2$$eT2
000117397 593__ $$aChemistry (miscellaneous)$$c2021$$dQ1
000117397 593__ $$aCatalysis$$c2021$$dQ1
000117397 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117397 700__ $$aBenedi A.$$uUniversidad de Zaragoza
000117397 700__ $$0(orcid)0000-0002-2315-9079$$aMarzo I.$$uUniversidad de Zaragoza
000117397 700__ $$aGarcía-Otín A.L.
000117397 700__ $$0(orcid)0000-0002-1218-7218$$aFernández-Moreira V.$$uUniversidad de Zaragoza
000117397 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno M. Concepción
000117397 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000117397 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000117397 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000117397 773__ $$g27, 38 (2021), 9885-9897$$pChemistry (Weinh.)$$tChemistry - A European Journal$$x0947-6539
000117397 8564_ $$s1997358$$uhttps://zaguan.unizar.es/record/117397/files/texto_completo.pdf$$yVersión publicada
000117397 8564_ $$s2895475$$uhttps://zaguan.unizar.es/record/117397/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117397 909CO $$ooai:zaguan.unizar.es:117397$$particulos$$pdriver
000117397 951__ $$a2023-05-18-16:04:33
000117397 980__ $$aARTICLE