000117405 001__ 117405
000117405 005__ 20230519145609.0
000117405 0247_ $$2doi$$a10.3390/diagnostics11061036
000117405 0248_ $$2sideral$$a127881
000117405 037__ $$aART-2021-127881
000117405 041__ $$aeng
000117405 100__ $$0(orcid)0000-0002-5869-4450$$aPascual-Mancho J.$$uUniversidad de Zaragoza
000117405 245__ $$aInfluence of cerebral vasodilation on blood reelin levels in growth restricted fetuses
000117405 260__ $$c2021
000117405 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117405 5203_ $$aFetal growth restriction (FGR) is one of the most important obstetric pathologies. It is frequently caused by placental insufficiency. Previous studies have shown a relationship between FGR and impaired new-born neurodevelopment, although the molecular mechanisms involved in this association have not yet been completely clarified. Reelin is an extracellular matrix glycoprotein involved in development of neocortex, hippocampus, cerebellum and spinal cord. Reelin has been demonstrated to play a key role in regulating perinatal neurodevelopment and to contribute to the emergence and development of various psychiatric pathologies, and its levels are highly influenced by pathological conditions of hypoxia. The purpose of this article is to study whether reelin levels in new-borns vary as a function of severity of fetal growth restriction by gestational age and sex. We sub-grouped fetuses in: normal weight group (Group 1, n = 17), FGR group with normal umbilical artery Doppler and cerebral redistribution at middle cerebral artery Doppler (Group 2, n = 9), and FGR with abnormal umbilical artery Doppler (Group 3, n = 8). Our results show a significant association of elevated Reelin levels in FGR fetuses with cerebral blood redistribution compared to the normal weight group and the FGR with abnormal umbilical artery group. Future research should focus on further expanding the knowledge of the relationship of reelin and its regulated products with neurodevelopment impairment in new-borns with FGR and should include larger and more homogeneous samples and the combined use of different in vivo techniques in neonates with impaired growth during their different adaptive phases. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
000117405 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI18-00912
000117405 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117405 590__ $$a3.992$$b2021
000117405 592__ $$a0.658$$b2021
000117405 594__ $$a2.4$$b2021
000117405 591__ $$aMEDICINE, GENERAL & INTERNAL$$b60 / 172 = 0.349$$c2021$$dQ2$$eT2
000117405 593__ $$aClinical Biochemistry$$c2021$$dQ2
000117405 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117405 700__ $$aPintado-Recarte P.
000117405 700__ $$aRomero-Román C.
000117405 700__ $$aMorales-Camino J.C.
000117405 700__ $$aHernández-Martin C.
000117405 700__ $$aBujan J.
000117405 700__ $$aOrtega M.A.
000117405 700__ $$aDe León-Luis J.
000117405 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000117405 773__ $$g11, 6 (2021), 1036 [11 pp]$$tDiagnostics$$x2075-4418
000117405 8564_ $$s1131591$$uhttps://zaguan.unizar.es/record/117405/files/texto_completo.pdf$$yVersión publicada
000117405 8564_ $$s2890633$$uhttps://zaguan.unizar.es/record/117405/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117405 909CO $$ooai:zaguan.unizar.es:117405$$particulos$$pdriver
000117405 951__ $$a2023-05-18-16:07:20
000117405 980__ $$aARTICLE