000117429 001__ 117429 000117429 005__ 20240319080957.0 000117429 0247_ $$2doi$$a10.3390/nu14051033 000117429 0248_ $$2sideral$$a128674 000117429 037__ $$aART-2022-128674 000117429 041__ $$aeng 000117429 100__ $$aMartinez, Victoria Gil$$uUniversidad de Zaragoza 000117429 245__ $$aVitamin Supplementation and Dementia: A Systematic Review 000117429 260__ $$c2022 000117429 5060_ $$aAccess copy available to the general public$$fUnrestricted 000117429 5203_ $$aBackground: Dementia is a syndrome characterized by progressive cognitive impairment that interferes with independent function in daily activities. Symptoms of dementia depend on its cause and vary greatly between individuals. There is extensive evidence supporting a relationship between diet and cognitive functions. This systematic review studies the efficacy of using vitamin supplements in the diet as a solution to nutritional deficiencies and the prevention of dementia and mild cognitive impairment. Methods: An intensive search of different databases (PubMed, Web of Science, and Cochrane CENTRAL) was performed. Articles that were published between 2011 and November 2021 were retrieved using the mentioned search strategy. This systematic review has been conducted according to the PRISMA statement. Results: Folic acid supplementation proved to have better outcomes on cognitive tests than their respective control groups. The combined supplementation of folic acid and vitamin B12 showed some discrepancies between studies. Thiamine as supplementation did not only prove to have a positive impact on cognitive performance when given alone but also when given in combination with folic acid. Regarding vitamin D supplementation, the results observed were not so encouraging. A concomitant supplementation of low-dose vitamin E and vitamin C was also not associated with an improvement of cognitive function. Conclusions: The findings of this systematic review suggest that supplementation of B Complex vitamins, especially folic acid, may have a positive effect on delaying and preventing the risk of cognitive decline. Ascorbic acid and a high dose of vitamin E, when given separately, also showed positive effects on cognitive performance, but there is not sufficient evidence to support their use. The results of vitamin D supplementation trials are not conclusive in assessing the potential benefits that vitamin D might have on cognition. 000117429 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000117429 590__ $$a5.9$$b2022 000117429 592__ $$a1.291$$b2022 000117429 591__ $$aNUTRITION & DIETETICS$$b17 / 87 = 0.195$$c2022$$dQ1$$eT1 000117429 593__ $$aNutrition and Dietetics$$c2022$$dQ1 000117429 593__ $$aFood Science$$c2022$$dQ1 000117429 594__ $$a9.0$$b2022 000117429 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000117429 700__ $$0(orcid)0000-0002-1275-2600$$aAvedillo Salas, Ana$$uUniversidad de Zaragoza 000117429 700__ $$aSantande Ballestin, Sonia 000117429 7102_ $$11012$$2315$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Farmacología 000117429 773__ $$g14, 5 (2022), 1033 [23 pp]$$pNutrients$$tNutrients$$x2072-6643 000117429 8564_ $$s842275$$uhttps://zaguan.unizar.es/record/117429/files/texto_completo.pdf$$yVersión publicada 000117429 8564_ $$s2774023$$uhttps://zaguan.unizar.es/record/117429/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000117429 909CO $$ooai:zaguan.unizar.es:117429$$particulos$$pdriver 000117429 951__ $$a2024-03-18-13:44:43 000117429 980__ $$aARTICLE