117435 20240319080957.0 doi 10.1002/mabi.202100528 sideral 128686 ART-2022-128686 eng Abad, Miriam Universidad de Zaragoza (orcid)0000-0002-8677-3316 Microfluidic Synthesis of Block Copolymer Micelles: Application as Drug Nanocarriers and as Photothermal Transductors When Loading Pd Nanosheets 2022 Access copy available to the general public Unrestricted The synthesis of polymeric nanoparticles from a block copolymer based on poly(ethylene glycol) and a polymethacrylate containing the nucleobase analog 2, 6-diacylaminopyridine is optimized by microfluidics to obtain homogeneous spherical micelles. Loading and delivery properties are studied using naproxen as a model. The incorporation of a Pd precursor in the polymer organic solution fed into the micromixer allows the preparation of Pd(II) precursor-polymer hybrid systems and the subsequent reduction with CO leads to the in situ synthesis of Pd nanosheets inside of the hydrophobic core of the polymeric micelles. This methodology is highly efficient to yield all polymeric nanoparticles loaded with Pd nanosheets as detected by electron microscopy and energy-dispersive X-ray spectroscopy. The cell viability of these Pd nanosheets-containing polymeric nanoparticles is evaluated using five cell lines, showing a high cytocompatibility at the tested concentrations without detrimental effects in cell membrane and nuclei. Furthermore, the use of these hybrid polymeric nanoparticles as photothermal transductors is evaluated using near infrared as irradiation source as well as its application in photothermal therapy using different cell lines demonstrating a high efficiency in all cell cultures. info:eu-repo/grantAgreement/ES/DGA-FSE/E47-17R info:eu-repo/grantAgreement/ES/ISCIII-IIS/MS19-00092 info:eu-repo/grantAgreement/ES/MICINN/RTI2018-099019-A-I00 info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 4.6 2022 POLYMER SCIENCE 18 / 85 = 0.212 2022 Q1 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 97 / 285 = 0.34 2022 Q2 T2 MATERIALS SCIENCE, BIOMATERIALS 21 / 45 = 0.467 2022 Q2 T2 0.855 2022 Materials Chemistry 2022 Q1 Polymers and Plastics 2022 Q1 Biomaterials 2022 Q2 Bioengineering 2022 Q2 Biotechnology 2022 Q2 8.4 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Mendoza, Gracia (orcid)0000-0003-2293-363X Uson, Laura (orcid)0000-0002-4678-7465 Arruebo, Manuel Universidad de Zaragoza (orcid)0000-0003-3165-0156 Piñol, Milagros Universidad de Zaragoza (orcid)0000-0001-5556-2172 Sebastian, Victor Universidad de Zaragoza (orcid)0000-0002-6873-5244 Oriol, Luis Universidad de Zaragoza (orcid)0000-0002-0922-5615 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 22, 5 (2022), 2100528 [14 pp] Macromol. biosci. Macromolecular Bioscience 1616-5187 5830197 http://zaguan.unizar.es/record/117435/files/texto_completo.pdf Versión publicada 2636295 http://zaguan.unizar.es/record/117435/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:117435 articulos driver 2024-03-18-13:45:39 ARTICLE