000117449 001__ 117449
000117449 005__ 20240319080959.0
000117449 0247_ $$2doi$$a10.1016/j.isci.2022.103822
000117449 0248_ $$2sideral$$a128128
000117449 037__ $$aART-2022-128128
000117449 041__ $$aeng
000117449 100__ $$0(orcid)0000-0002-2954-1068$$aGarcía-Mendívil, Laura$$uUniversidad de Zaragoza
000117449 245__ $$aAnalysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
000117449 260__ $$c2022
000117449 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117449 5203_ $$aAge-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age-associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics. © 2022 The Author(s)
000117449 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group$$9info:eu-repo/grantAgreement/ES/DGA/LMP128_21$$9info:eu-repo/grantAgreement/ES/DGA/LMP94_21$$9info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-105674RB-I00
000117449 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000117449 590__ $$a5.8$$b2022
000117449 592__ $$a1.624$$b2022
000117449 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 73 = 0.205$$c2022$$dQ1$$eT1
000117449 593__ $$aMultidisciplinary$$c2022$$dQ1
000117449 594__ $$a6.9$$b2022
000117449 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117449 700__ $$0(orcid)0000-0002-3194-7796$$aPérez-Zabalza, María
000117449 700__ $$0(orcid)0000-0003-2946-3044$$aMountris, Konstantinos
000117449 700__ $$aDuwé, Sam
000117449 700__ $$aSmisdom, Nick
000117449 700__ $$0(orcid)0000-0002-8133-2124$$aPérez, Marta$$uUniversidad de Zaragoza
000117449 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, Lluis$$uUniversidad de Zaragoza
000117449 700__ $$aWolfs, Esther
000117449 700__ $$aDriesen, Ronald B.
000117449 700__ $$aVallejo-Gil, José María
000117449 700__ $$aFresneda-Roldán, Pedro Carlos
000117449 700__ $$aFañanás-Mastral, Javier
000117449 700__ $$aVázquez-Sancho, Manuel
000117449 700__ $$0(orcid)0000-0001-7482-2582$$aMatamala-Adell, Marta$$uUniversidad de Zaragoza
000117449 700__ $$aSorribas-Berjón, Juan Fernando
000117449 700__ $$aBellido-Morales, Javier André
000117449 700__ $$aMancebón-Sierra, Francisco Javier
000117449 700__ $$aVaca-Núñez, Alexander Sebastián
000117449 700__ $$0(orcid)0000-0002-2225-308X$$aBallester-Cuenca, Carlos$$uUniversidad de Zaragoza
000117449 700__ $$0(orcid)0000-0001-5348-924X$$aOliván-Viguera, Aida
000117449 700__ $$aDiez, Emiliano
000117449 700__ $$0(orcid)0000-0003-3982-1263$$aOrdovás, Laura
000117449 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000117449 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000117449 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000117449 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000117449 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000117449 773__ $$g25, 2 (2022), 103822 [20 pp]$$piScience$$tISCIENCE$$x2589-0042
000117449 8564_ $$s3935819$$uhttps://zaguan.unizar.es/record/117449/files/texto_completo.pdf$$yVersión publicada
000117449 8564_ $$s1399899$$uhttps://zaguan.unizar.es/record/117449/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117449 909CO $$ooai:zaguan.unizar.es:117449$$particulos$$pdriver
000117449 951__ $$a2024-03-18-14:01:13
000117449 980__ $$aARTICLE