000117452 001__ 117452
000117452 005__ 20240319080959.0
000117452 0247_ $$2doi$$a10.3390/biomedicines10010019
000117452 0248_ $$2sideral$$a128136
000117452 037__ $$aART-2022-128136
000117452 041__ $$aeng
000117452 100__ $$aGil-Melgosa, Lara
000117452 245__ $$aMuscular and tendon degeneration after achilles rupture: new insights into future repair strategies
000117452 260__ $$c2022
000117452 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117452 5203_ $$aAchilles tendon rupture is a frequent injury with an increasing incidence. After clinical surgical repair, aimed at suturing the tendon stumps back into their original position, the repaired Achilles tendon is often plastically deformed and mechanically less strong than the pre-injured tissue, with muscle fatty degeneration contributing to function loss. Despite clinical outcomes, pre-clinical research has mainly focused on tendon structural repair, with a lack of knowledge regarding injury progression from tendon to muscle and its consequences on muscle degenerative/regenerative processes and function. Here, we characterize the morphological changes in the tendon, the myotendinous junction and muscle belly in a mouse model of Achilles tendon complete rupture, finding cellular and fatty infiltration, fibrotic tissue accumulation, muscle stem cell decline and collagen fiber disorganization. We use novel imaging technologies to accurately relate structural alterations in tendon fibers to pathological changes, which further explain the loss of muscle mechanical function after tendon rupture. The treatment of tendon injuries remains a challenge for orthopedics. Thus, the main goal of this study is to bridge the gap between clinicians'' knowledge and research to address the underlying pathophysiology of ruptured Achilles tendon and its consequences in the gastrocnemius. Such studies are necessary if current practices in regenerative medicine for Achilles tendon ruptures are to be improved.
000117452 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-094494-B-C22$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113822RB-C22$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113822RB-C21$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R
000117452 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117452 590__ $$a4.7$$b2022
000117452 592__ $$a0.897$$b2022
000117452 591__ $$aPHARMACOLOGY & PHARMACY$$b68 / 278 = 0.245$$c2022$$dQ1$$eT1
000117452 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000117452 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b92 / 285 = 0.323$$c2022$$dQ2$$eT1
000117452 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2022$$dQ2
000117452 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b54 / 136 = 0.397$$c2022$$dQ2$$eT2
000117452 594__ $$a3.7$$b2022
000117452 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117452 700__ $$0(orcid)0000-0002-6870-0594$$aGrasa, Jorge$$uUniversidad de Zaragoza
000117452 700__ $$aUrbiola, Ainhoa
000117452 700__ $$aLlombart, Rafael
000117452 700__ $$aSusaeta Ruiz, Miguel
000117452 700__ $$aMontiel, Veronica
000117452 700__ $$aEderra, Cristina
000117452 700__ $$0(orcid)0000-0001-9713-1813$$aCalvo, Begona$$uUniversidad de Zaragoza
000117452 700__ $$aAriz, Mikel
000117452 700__ $$aRipalda-Cemborain, Purificacion
000117452 700__ $$aProsper, Felipe
000117452 700__ $$aOrtiz-de-Solorzano, Carlos
000117452 700__ $$aPons-Villanueva, Juan
000117452 700__ $$aPerez Ruiz, Ana
000117452 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000117452 773__ $$g10, 1 (2022), 19 [16 pp]$$tBiomedicines$$x2227-9059
000117452 8564_ $$s5436604$$uhttps://zaguan.unizar.es/record/117452/files/texto_completo.pdf$$yVersión publicada
000117452 8564_ $$s2726931$$uhttps://zaguan.unizar.es/record/117452/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117452 909CO $$ooai:zaguan.unizar.es:117452$$particulos$$pdriver
000117452 951__ $$a2024-03-18-14:01:31
000117452 980__ $$aARTICLE