000117455 001__ 117455
000117455 005__ 20240319081000.0
000117455 0247_ $$2doi$$a10.3390/antiox11040733
000117455 0248_ $$2sideral$$a128764
000117455 037__ $$aART-2022-128764
000117455 041__ $$aeng
000117455 100__ $$aPaesa, M.$$uUniversidad de Zaragoza
000117455 245__ $$aValorization of onion waste by obtaining extracts rich in phenolic compounds and feasibility of its therapeutic use on colon cancer
000117455 260__ $$c2022
000117455 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117455 5203_ $$aIn this study, the total phenolic content, the antioxidant and antiproliferative activities of onion waste extracts were characterized. Some phenolic compounds present in the extracts were also identified and quantified by HPLC-DAD. Additionally, an in-silico analysis was performed to identify the phenolic compounds with the highest intestinal absorption and Caco-2 permeability. The onion extract possessed a high amount of phenolic compounds (177 ± 9 mg/g extract) and had an effective antioxidant capacity measured by ABTS, FRAP and DPPH assays. Regarding the antiproliferative activity, the onion extracts produced cell cycle arrest in the S phase with p53 activation, intrinsic apoptosis (mitochondrial membrane potential modification) and caspase 3 activation. Likewise, onion waste increased intracellular ROS with possible NF-kB activation causing a proteasome down regulation. In addition, the extracts protected the intestine against oxidative stress induced by H2O2 . According to the in-silico analysis, these results could be related to the higher Caco-2 permeability to protocatechuic acid. Therefore, this study provides new insights regarding the potential use of these types of extract as functional ingredients with antioxidant and antiproliferative properties and as medicinal agents in diseases related to oxidative stress, such as cancer. In addition, its valorization would contribute to the circular economy. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
000117455 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/DGA-FSE/B16-20R$$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent$$9info:eu-repo/grantAgreement/ES/MICINN-ISCIIII-FEDER/PID2019-104915RB-I00$$9info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123
000117455 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117455 590__ $$a7.0$$b2022
000117455 592__ $$a1.084$$b2022
000117455 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b46 / 285 = 0.161$$c2022$$dQ1$$eT1
000117455 593__ $$aBiochemistry$$c2022$$dQ1
000117455 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b13 / 142 = 0.092$$c2022$$dQ1$$eT1
000117455 593__ $$aClinical Biochemistry$$c2022$$dQ1
000117455 591__ $$aCHEMISTRY, MEDICINAL$$b6 / 60 = 0.1$$c2022$$dQ1$$eT1
000117455 593__ $$aFood Science$$c2022$$dQ1
000117455 593__ $$aPhysiology$$c2022$$dQ1
000117455 593__ $$aMolecular Biology$$c2022$$dQ2
000117455 593__ $$aCell Biology$$c2022$$dQ2
000117455 594__ $$a8.8$$b2022
000117455 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117455 700__ $$aNogueira, D. P.
000117455 700__ $$aVelderrain-Rodríguez, G.
000117455 700__ $$aEsparza, I.
000117455 700__ $$aJiménez-Moreno, N.
000117455 700__ $$aMendoza, G.
000117455 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza
000117455 700__ $$aMartin-Belloso, O.
000117455 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez-Yoldi, M. J.$$uUniversidad de Zaragoza
000117455 700__ $$aAncín-Azpilicueta, C.
000117455 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000117455 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000117455 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000117455 773__ $$g11, 4 (2022), 733 [18 pp]$$pAntioxidants$$tAntioxidants$$x2076-3921
000117455 8564_ $$s526809$$uhttps://zaguan.unizar.es/record/117455/files/texto_completo.pdf$$yVersión publicada
000117455 8564_ $$s2581129$$uhttps://zaguan.unizar.es/record/117455/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117455 909CO $$ooai:zaguan.unizar.es:117455$$particulos$$pdriver
000117455 951__ $$a2024-03-18-14:02:00
000117455 980__ $$aARTICLE