000117466 001__ 117466
000117466 005__ 20240319081000.0
000117466 0247_ $$2doi$$a10.1016/j.colsurfb.2022.112363
000117466 0248_ $$2sideral$$a128143
000117466 037__ $$aART-2022-128143
000117466 041__ $$aeng
000117466 100__ $$aGonzález-Domínguez, J. M.
000117466 245__ $$aIntrinsic and selective activity of functionalized carbon nanotube/nanocellulose platforms against colon cancer cells
000117466 260__ $$c2022
000117466 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117466 5203_ $$aGiven their large surface area and versatile chemical reactivity, single-walled carbon nanotubes (SWCNTs) are regarded as the basis of new pharmacological complexes. In this study, SWCNTs are chemically functionalized with fluorescein, folic acid, and capecitabine, a drug that is commonly used against colorectal cancer. These functionalized SWCNTs are dispersed in water by taking advantage of their synergistic interaction with type-II nanocrystalline cellulose (II-NCC), and the resulting colloidal system is tested in vitro on both normal (differentiated) and cancerous (proliferative) human colon cells (Caco-2). The functionalized SWCNT/II-NCC hybrids show a higher activity than the reference (capecitabine) against the Caco-2 cancer cell line. However, this effect appears to be intrinsically associated with the SWCNT/II-NCC complex, particularly boosted by fluorescein, as the presence of capecitabine is not required. In addition, confocal microscopy fluorescence imaging using cell cultures highlights the enormous potential of this nanohybrid platform for colon cancer theranostics. © 2022 The Authors
000117466 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A20-20R$$9info:eu-repo/grantAgreement/ES/DGA/T03-17R$$9info:eu-repo/grantAgreement/ES/DGA/T03-20R
000117466 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000117466 590__ $$a5.8$$b2022
000117466 592__ $$a0.868$$b2022
000117466 591__ $$aBIOPHYSICS$$b9 / 70 = 0.129$$c2022$$dQ1$$eT1
000117466 593__ $$aPhysical and Theoretical Chemistry$$c2022$$dQ1
000117466 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b14 / 45 = 0.311$$c2022$$dQ2$$eT1
000117466 593__ $$aColloid and Surface Chemistry$$c2022$$dQ2
000117466 591__ $$aCHEMISTRY, PHYSICAL$$b51 / 161 = 0.317$$c2022$$dQ2$$eT1
000117466 593__ $$aSurfaces and Interfaces$$c2022$$dQ2
000117466 593__ $$aBiotechnology$$c2022$$dQ2
000117466 593__ $$aMedicine (miscellaneous)$$c2022$$dQ2
000117466 594__ $$a11.0$$b2022
000117466 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117466 700__ $$0(orcid)0000-0002-5306-9365$$aGrasa, L.$$uUniversidad de Zaragoza
000117466 700__ $$aFrontiñán-Rubio, J.
000117466 700__ $$aAbás, E.
000117466 700__ $$aDomínguez-Alfaro, A.
000117466 700__ $$0(orcid)0000-0003-4758-3998$$aMesonero, J. E.$$uUniversidad de Zaragoza
000117466 700__ $$aCriado, A.
000117466 700__ $$0(orcid)0000-0002-3134-8566$$aAnsón-Casaos, A.
000117466 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000117466 773__ $$g212, 112363 (2022), [14 pp]$$pColloids surf., B Biointerfaces$$tCOLLOIDS AND SURFACES B-BIOINTERFACES$$x0927-7765
000117466 8564_ $$s14443086$$uhttps://zaguan.unizar.es/record/117466/files/texto_completo.pdf$$yVersión publicada
000117466 8564_ $$s2588683$$uhttps://zaguan.unizar.es/record/117466/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117466 909CO $$ooai:zaguan.unizar.es:117466$$particulos$$pdriver
000117466 951__ $$a2024-03-18-14:03:23
000117466 980__ $$aARTICLE