117466 20240319081000.0 doi 10.1016/j.colsurfb.2022.112363 sideral 128143 ART-2022-128143 eng González-Domínguez, J. M. Intrinsic and selective activity of functionalized carbon nanotube/nanocellulose platforms against colon cancer cells 2022 Access copy available to the general public Unrestricted Given their large surface area and versatile chemical reactivity, single-walled carbon nanotubes (SWCNTs) are regarded as the basis of new pharmacological complexes. In this study, SWCNTs are chemically functionalized with fluorescein, folic acid, and capecitabine, a drug that is commonly used against colorectal cancer. These functionalized SWCNTs are dispersed in water by taking advantage of their synergistic interaction with type-II nanocrystalline cellulose (II-NCC), and the resulting colloidal system is tested in vitro on both normal (differentiated) and cancerous (proliferative) human colon cells (Caco-2). The functionalized SWCNT/II-NCC hybrids show a higher activity than the reference (capecitabine) against the Caco-2 cancer cell line. However, this effect appears to be intrinsically associated with the SWCNT/II-NCC complex, particularly boosted by fluorescein, as the presence of capecitabine is not required. In addition, confocal microscopy fluorescence imaging using cell cultures highlights the enormous potential of this nanohybrid platform for colon cancer theranostics. © 2022 The Authors info:eu-repo/grantAgreement/ES/DGA/A20-20R info:eu-repo/grantAgreement/ES/DGA/T03-17R info:eu-repo/grantAgreement/ES/DGA/T03-20R info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 5.8 2022 BIOPHYSICS 9 / 70 = 0.129 2022 Q1 T1 MATERIALS SCIENCE, BIOMATERIALS 14 / 45 = 0.311 2022 Q2 T1 CHEMISTRY, PHYSICAL 51 / 161 = 0.317 2022 Q2 T1 0.868 2022 Physical and Theoretical Chemistry 2022 Q1 Colloid and Surface Chemistry 2022 Q2 Surfaces and Interfaces 2022 Q2 Biotechnology 2022 Q2 Medicine (miscellaneous) 2022 Q2 11.0 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Grasa, L. Universidad de Zaragoza (orcid)0000-0002-5306-9365 Frontiñán-Rubio, J. Abás, E. Domínguez-Alfaro, A. Mesonero, J. E. Universidad de Zaragoza (orcid)0000-0003-4758-3998 Criado, A. Ansón-Casaos, A. (orcid)0000-0002-3134-8566 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 212, 112363 (2022), [14 pp] Colloids surf., B Biointerfaces COLLOIDS AND SURFACES B-BIOINTERFACES 0927-7765 14443086 http://zaguan.unizar.es/record/117466/files/texto_completo.pdf Versión publicada 2588683 http://zaguan.unizar.es/record/117466/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:117466 articulos driver 2024-03-18-14:03:23 ARTICLE