000117474 001__ 117474
000117474 005__ 20240319081000.0
000117474 0247_ $$2doi$$a10.3389/fphar.2022.825522
000117474 0248_ $$2sideral$$a128780
000117474 037__ $$aART-2022-128780
000117474 041__ $$aeng
000117474 100__ $$aCalpe-López, C.
000117474 245__ $$aBrief maternal separation inoculates against the effects of social stress on depression-like behavior and cocaine reward in mice
000117474 260__ $$c2022
000117474 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117474 5203_ $$aExposure to intermittent repeated social defeat (IRSD) increases the vulnerability of mice to the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm. According to the “inoculation of stress” hypothesis, a brief period of maternal separation (MS) can provide protection against the negative effects of IRSD. The aim of the present study was to assess whether exposure to a brief episode of MS prevents the subsequent short-term effects of IRSD on depression- and anxiety-like behaviors and to explore its long-term effects on cocaine CPP in mice. Four groups of male C57BL/6 mice were employed; two groups were separated from their mother 6 h on postnatal day (PND) 9], while the other two groups were not (controls). On PND 47, 50, 53 and 56, mice that had experienced MS were exposed to social defeat in the cage of an aggressive resident mouse (MS + IRSD group) or were allowed to explore an empty cage (MS + EXPL group). The same procedure was performed with control mice that had not experienced MS (CONTROL + IRSD and CONTROL + EXPL groups). On PND57-58, all the mice performed the elevated plus maze and the hole-board, social interaction and splash tests. Three weeks after the last episode of defeat, all the mice underwent the CPP procedure with cocaine (1 mg/kg). Irrespective of whether or not MS had taken place, a reduction in open arms measures, dips, and social interaction was observed in mice that experienced IRSD. A higher latency of grooming and acquisition of cocaine-induced CPP were observed only in mice exposed to IRSD alone (CONTROL + IRSD). These results suggest that exposure to a brief episode of stress early in life increases the subsequent resilience of animals to the effects of social stress on vulnerability to cocaine. Copyright © 2022 Calpe-López, Martínez-Caballero, García-Pardo and Aguilar.
000117474 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PSI2017-83023
000117474 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117474 590__ $$a5.6$$b2022
000117474 592__ $$a1.064$$b2022
000117474 591__ $$aPHARMACOLOGY & PHARMACY$$b44 / 278 = 0.158$$c2022$$dQ1$$eT1
000117474 593__ $$aPharmacology (medical)$$c2022$$dQ1
000117474 593__ $$aPharmacology$$c2022$$dQ1
000117474 594__ $$a6.3$$b2022
000117474 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117474 700__ $$aMartínez-Caballero, M. A.
000117474 700__ $$aGarcía-Pardo, M. P.$$uUniversidad de Zaragoza
000117474 700__ $$aAguilar, M. A.
000117474 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000117474 773__ $$g13, 825522 (2022), [15 pp]$$pFront. pharmacol.$$tFrontiers in Pharmacology$$x1663-9812
000117474 8564_ $$s2460219$$uhttps://zaguan.unizar.es/record/117474/files/texto_completo.pdf$$yVersión publicada
000117474 8564_ $$s2348947$$uhttps://zaguan.unizar.es/record/117474/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117474 909CO $$ooai:zaguan.unizar.es:117474$$particulos$$pdriver
000117474 951__ $$a2024-03-18-14:06:30
000117474 980__ $$aARTICLE