000117603 001__ 117603
000117603 005__ 20230519145514.0
000117603 0247_ $$2doi$$a10.1093/jac/dkab208
000117603 0248_ $$2sideral$$a124568
000117603 037__ $$aART-2021-124568
000117603 041__ $$aeng
000117603 100__ $$aMama, O.M.
000117603 245__ $$aPenicillin susceptibility among invasive MSSA infections: a multicentre study in 16 Spanish hospitals
000117603 260__ $$c2021
000117603 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117603 5203_ $$aObjectives: To determine the prevalence of penicillin susceptibility among MSSA causing bloodstream infections (BSIs) in 16 Spanish hospitals and to characterize the penicillin-susceptible MSSA (MSSA-PENS) isolates. Methods: A total of 1011 Staphylococcus aureus isolates were collected from blood cultures in 16 Spanish hospitals during 2018–19 (6–12 months) and their susceptibility to 18 antimicrobials was determined. The MSSA-PENS isolates were selected and examined by PCR to determine the presence of the blaZ gene, other resistance genes and the genes lukF/lukS-PV, eta, etb and tst. The immune evasion cluster (IEC) type was also analysed. All the MSSA-PENS isolates were submitted to S. aureus protein A (spa) typing and the clonal complexes (CCs) were assigned according to their spa type. Results: The prevalence of MSSA was 74.6% (754/1011) and 14.9% (151/1011) were MSSA-PENS-blaZnegative. MSSA-PENS-blaZnegative isolates (n = 151) were ascribed to 88 spa types and 11 CCs. The most frequent CCs were CC5 (35/151) and CC398 (25/151), with t002-CC5 and t571-CC398 being the most common lineages. Pan-susceptibility was identified in 117 of the 151 MSSA-PENS-blaZnegative isolates (77.5%). In the remaining isolates, erythromycin and clindamycin resistance was the most frequent resistance found, although tobramycin, ciprofloxacin, fusidic acid, mupirocin and/or tetracycline resistance was also detected. Thirty-eight MSSA-PENS-blaZnegative isolates were IEC negative and four isolates were Panton–Valentine leucocidin (‘PVL’) positive. Conclusions: A high penicillin susceptibility rate was detected among MSSA, opening therapeutic opportunities for BSIs. The emergence of new successful MSSA-PENS clones could be responsible for these data. The detection among MSSA-PENS-blaZnegative isolates of the clonal lineage CC398 or the absence of an IEC raises questions about their possible animal origin, requiring further analysis.
000117603 536__ $$9info:eu-repo/grantAgreement/ES/AEI-FEDER-ICS/SAF2016–76571-R$$9info:eu-repo/grantAgreement/ES/AEI/PID2019-106158RB-I00
000117603 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000117603 590__ $$a5.758$$b2021
000117603 592__ $$a1.495$$b2021
000117603 594__ $$a9.4$$b2021
000117603 591__ $$aPHARMACOLOGY & PHARMACY$$b54 / 279 = 0.194$$c2021$$dQ1$$eT1
000117603 593__ $$aInfectious Diseases$$c2021$$dQ1
000117603 591__ $$aINFECTIOUS DISEASES$$b32 / 96 = 0.333$$c2021$$dQ2$$eT2
000117603 593__ $$aPharmacology (medical)$$c2021$$dQ1
000117603 591__ $$aMICROBIOLOGY$$b39 / 138 = 0.283$$c2021$$dQ2$$eT1
000117603 593__ $$aMicrobiology (medical)$$c2021$$dQ1
000117603 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000117603 700__ $$aAspiroz, C.
000117603 700__ $$aLozano, C.
000117603 700__ $$aRuiz-Ripa, L.
000117603 700__ $$aAzcona, J.M.
000117603 700__ $$0(orcid)0000-0002-9742-1463$$aSeral, C.$$uUniversidad de Zaragoza
000117603 700__ $$aCercenado, E.
000117603 700__ $$aLópez-Cerero, L.
000117603 700__ $$aPalacián, P.
000117603 700__ $$aBelles-Belles, A.
000117603 700__ $$aBerdonces, P.
000117603 700__ $$aSiller, M.
000117603 700__ $$aAguirre-Quiñonero, A.
000117603 700__ $$aZarazaga, M.
000117603 700__ $$aTorres, C
000117603 700__ $$0(orcid)0000-0002-2519-701X$$aCastillo, J.$$uUniversidad de Zaragoza
000117603 700__ $$0(orcid)0000-0001-7294-245X$$aRezusta, A.$$uUniversidad de Zaragoza
000117603 700__ $$aCalleja, A.I.
000117603 700__ $$aon behalf of the Spanish Study Group of Clinical S. aureus CC398
000117603 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000117603 773__ $$g76, 10 (2021), 2519–2527$$pJ. antimicrob. chemother.$$tThe Journal of antimicrobial chemotherapy$$x0305-7453
000117603 8564_ $$s426113$$uhttps://zaguan.unizar.es/record/117603/files/texto_completo.pdf$$yPostprint
000117603 8564_ $$s2797067$$uhttps://zaguan.unizar.es/record/117603/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000117603 909CO $$ooai:zaguan.unizar.es:117603$$particulos$$pdriver
000117603 951__ $$a2023-05-18-15:14:43
000117603 980__ $$aARTICLE