000117623 001__ 117623 000117623 005__ 20240319081006.0 000117623 0247_ $$2doi$$a10.1016/j.neulet.2022.136619 000117623 0248_ $$2sideral$$a129169 000117623 037__ $$aART-2022-129169 000117623 041__ $$aeng 000117623 100__ $$aRódenas-González, F. 000117623 245__ $$aEffects of ketosis on cocaine-induced reinstatement in male mice; 000117623 260__ $$c2022 000117623 5060_ $$aAccess copy available to the general public$$fUnrestricted 000117623 5203_ $$aIn recent years, the benefits of the ketogenic diet (KD) on different psychiatric disorders have been gaining attention, but the substance abuse field is still unexplored. Some studies have reported that palatable food can modulate the rewarding effects of cocaine, but the negative metabolic consequences rule out the recommendation of using it as a complementary treatment. Thus, the main aim of this study was to evaluate the effects of the KD on cocaine conditioned place preference (CPP) during acquisition, extinction, and reinstatement. 41 OF1 male mice were employed to assess the effects of the KD on a 10 mg/kg cocaine-induced CPP. Animals were divided into three groups: SD, KD, and KD after the Post-Conditioning test. The results revealed that, while access to the KD did not block CPP acquisition, it did significantly reduce the number of sessions required to extinguish the drug-associated memories and it blocked the priming-induced reinstatement. © 2022 The Author(s) 000117623 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-112672RB-100 000117623 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000117623 590__ $$a2.5$$b2022 000117623 592__ $$a0.802$$b2022 000117623 591__ $$aNEUROSCIENCES$$b198 / 272 = 0.728$$c2022$$dQ3$$eT3 000117623 593__ $$aNeuroscience (miscellaneous)$$c2022$$dQ2 000117623 594__ $$a5.9$$b2022 000117623 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000117623 700__ $$0(orcid)0000-0001-5990-1266$$aBlanco-Gandía, M. C.$$uUniversidad de Zaragoza 000117623 700__ $$aMiñarro, J. 000117623 700__ $$aRodríguez-Arias, M. 000117623 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000117623 773__ $$g778 (2022), 136619 [6 pp]$$pNeurosci. lett.$$tNEUROSCIENCE LETTERS$$x0304-3940 000117623 8564_ $$s631050$$uhttps://zaguan.unizar.es/record/117623/files/texto_completo.pdf$$yVersión publicada 000117623 8564_ $$s2739619$$uhttps://zaguan.unizar.es/record/117623/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000117623 909CO $$ooai:zaguan.unizar.es:117623$$particulos$$pdriver 000117623 951__ $$a2024-03-18-14:42:09 000117623 980__ $$aARTICLE