000117624 001__ 117624 000117624 005__ 20240319081007.0 000117624 0247_ $$2doi$$a10.1016/j.aca.2022.339738 000117624 0248_ $$2sideral$$a129172 000117624 037__ $$aART-2022-129172 000117624 041__ $$aeng 000117624 100__ $$0(orcid)0000-0002-3916-9992$$aAramendía, M.$$uUniversidad de Zaragoza 000117624 245__ $$aA novel approach for adapting the standard addition method to single particle-ICP-MS for the accurate determination of NP size and number concentration in complex matrices; 35414390 000117624 260__ $$c2022 000117624 5060_ $$aAccess copy available to the general public$$fUnrestricted 000117624 5203_ $$aThis paper presents a novel approach, based on the standard addition method, for overcoming the matrix effects that often hamper the accurate characterization of nanoparticles (NPs) in complex samples via single particle inductively coupled plasma mass spectrometry (SP-ICP-MS). In this approach, calibration of the particle size is performed by two different methods: (i) by spiking a suspension of NPs standards of known size containing the analyte, or (ii) by spiking the sample with ionic standards; either way, the measured sensitivity is used in combination with the transport efficiency (TE) for sizing the NPs. Moreover, such transport efficiency can be readily obtained from the data obtained via both calibration methods mentioned above, so that the particle number concentration can also be determined. The addition of both ionic and NP standards can be performed on-line, by using a T-piece with two inlet lines of different dimensions. The smaller of the two is used for the standards, thus ensuring a constant and minimal sample dilution. As a result of the spiking of the samples, mixed histograms including the signal of the sample and that of the standards are obtained. However, the use of signal deconvolution approaches permits to extract the information, even in cases of signal populations overlapping. For proofing the concept, characterization of a 50 nm AuNPs suspension prepared in three different media (i.e., deionized water, 5% ethanol, and 2.5% tetramethyl ammonium hydroxide-TMAH) was carried out. Accurate results were obtained in all cases, in spite of the matrix effects detected in some media. Overall, the approach proposed offers flexibility, so it can be adapted to different situations, but it might be specially indicated for samples for which the matrix is not fully known and/or dilution is not possible/recommended. © 2022 The Authors 000117624 536__ $$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PGC2018-093753-B-I00$$9info:eu-repo/grantAgreement/ES/DGA/E43-20R$$9info:eu-repo/grantAgreement/ES/AEI/PID2019-105660RB-C21-AEI-10.13039-501100011033 000117624 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000117624 590__ $$a6.2$$b2022 000117624 592__ $$a1.042$$b2022 000117624 591__ $$aCHEMISTRY, ANALYTICAL$$b8 / 86 = 0.093$$c2022$$dQ1$$eT1 000117624 593__ $$aAnalytical Chemistry$$c2022$$dQ1 000117624 593__ $$aSpectroscopy$$c2022$$dQ1 000117624 593__ $$aEnvironmental Chemistry$$c2022$$dQ2 000117624 593__ $$aBiochemistry$$c2022$$dQ2 000117624 594__ $$a10.7$$b2022 000117624 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000117624 700__ $$aGarcía-Mesa, J. C. 000117624 700__ $$aAlonso, E. V. 000117624 700__ $$aGarde, R. 000117624 700__ $$aBazo, A. 000117624 700__ $$0(orcid)0000-0002-7532-2720$$aResano, J.$$uUniversidad de Zaragoza 000117624 700__ $$0(orcid)0000-0002-7450-8769$$aResano, M.$$uUniversidad de Zaragoza 000117624 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000117624 7102_ $$15007$$2035$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Arquit.Tecnología Comput. 000117624 773__ $$g1205 (2022), 339738 [12 pp]$$pAnal. chim. acta$$tAnalytica Chimica Acta$$x0003-2670 000117624 8564_ $$s2297414$$uhttps://zaguan.unizar.es/record/117624/files/texto_completo.pdf$$yVersión publicada 000117624 8564_ $$s2091675$$uhttps://zaguan.unizar.es/record/117624/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000117624 909CO $$ooai:zaguan.unizar.es:117624$$particulos$$pdriver 000117624 951__ $$a2024-03-18-14:42:20 000117624 980__ $$aARTICLE