doi:10.1002/chir.23475engLopez-Ram-de-Viu, PilarGalvez, Jose A.Diaz-de-Villegas, Maria D.Synthesis, resolution, and absolute configuration determination of a vicinal amino alcohol with axial chirality. Application to the synthesis of new box and pybox ligandsART-2022-129231New racemic vicinal amino alcohol derivatives with 4-benzylidenecyclohexane skeleton and axial chirality have been prepared. A preparatively easy and efficient protocol for resolution of the N-benzoylamino alcohol is described. Using a 250 x 20 mm (L x ID) Chiralpak (R) IA column, and the appropriate mixture of n-hexane/ethanol/chloroform as eluent, both enantiomers of N-benzoylamino alcohol 3 are obtained with >99% enantiomeric excess (ee) by successive injections of a solution of the racemic sample in chloroform. The obtained axially chiral vicinal amino alcohol is used to synthesize structurally novel bisoxazoline ligands in high yields.2022http://zaguan.unizar.es/record/11763410.1002/chir.23475http://zaguan.unizar.es/record/117634oai:zaguan.unizar.es:117634info:eu-repo/grantAgreement/ES/DGA/E45-20RChirality 34, 8 (2022), 1140-1150by-nc-ndhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccess