000117643 001__ 117643
000117643 005__ 20240319081015.0
000117643 0247_ $$2doi$$a10.3390/agronomy12040885
000117643 0248_ $$2sideral$$a128966
000117643 037__ $$aART-2022-128966
000117643 041__ $$aeng
000117643 100__ $$aSánchez-Hernández, E.
000117643 245__ $$aAntifungal activity of methylxanthines against grapevine trunk diseases
000117643 260__ $$c2022
000117643 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117643 5203_ $$aMethylxanthines, found in the seeds, leaves, and fruits of some plants, are receiving increasing attention as promising treatments for wood-degrading fungi. The aim of the study presented herein was to explore the potential applications of caffeine, four caffeine derivatives (viz. 8-bromo-caffeine, 8-iodo-caffeine, 8-(4-fluorophenoxy)-caffeine, and 8-(2, 3, 5, 6-tetrafluoroalcoxy)-caffeine), and theophylline as antifungals for Botryosphaeriaceae species associated with grapevine trunk diseases (GTDs). In vitro susceptibility tests were conducted to assess the antimycotic activity of the aforementioned compounds and their conjugated complexes with chitosan oligomers (COS). Caffeine, Br-caffeine, and I-caffeine exhibited higher efficacies than imidazole, the chosen antifungal control. Moreover, a strong synergistic behavior between COS and the methylxanthine derivatives was observed. The COS–I-caffeine complex showed the best overall performance against the phytopathogenic fungi with EC90 values of 471, 640, and 935 µg mL-1 for D. seriata, D. viticola, and N. parvum, respectively. In a second step, combinations of the new treatments with imidazole were also explored, resulting in further activity enhancement and EC90 values of 425, 271, and 509 mL-1 against D. seriata, D. viticola, and N. parvum, respectively, for the COS–I-caffeine-imidazole ternary compound. Given the high in vitro efficacy of these formulations for the control of GTDs, they may deserve further investigation with in vivo and field bioassays as an alternative to conventional fungicides. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
000117643 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117643 590__ $$a3.7$$b2022
000117643 592__ $$a0.663$$b2022
000117643 591__ $$aAGRONOMY$$b16 / 88 = 0.182$$c2022$$dQ1$$eT1
000117643 593__ $$aAgronomy and Crop Science$$c2022$$dQ1
000117643 591__ $$aPLANT SCIENCES$$b60 / 239 = 0.251$$c2022$$dQ2$$eT1
000117643 594__ $$a5.2$$b2022
000117643 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117643 700__ $$aAndrés-Juan, C.
000117643 700__ $$aBuzón-Durán, L.
000117643 700__ $$aCorrea-Guimaraes, A.
000117643 700__ $$aMartín-Gil, J.
000117643 700__ $$0(orcid)0000-0003-2713-2786$$aMartín-Ramos, P.$$uUniversidad de Zaragoza
000117643 7102_ $$15011$$2500$$aUniversidad de Zaragoza$$bDpto. CC.Agrar.y Medio Natural$$cArea Ingeniería Agroforestal
000117643 773__ $$g12, 4 (2022), 885 [19 pp.]$$pAgronomy (Basel)$$tAgronomy (Basel)$$x2073-4395
000117643 8564_ $$s4581822$$uhttps://zaguan.unizar.es/record/117643/files/texto_completo.pdf$$yVersión publicada
000117643 8564_ $$s2701678$$uhttps://zaguan.unizar.es/record/117643/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117643 909CO $$ooai:zaguan.unizar.es:117643$$particulos$$pdriver
000117643 951__ $$a2024-03-18-15:32:28
000117643 980__ $$aARTICLE