000117688 001__ 117688 000117688 005__ 20251113150202.0 000117688 0247_ $$2doi$$a10.3389/fnut.2022.881465 000117688 0248_ $$2sideral$$a129178 000117688 037__ $$aART-2022-129178 000117688 041__ $$aeng 000117688 100__ $$0(orcid)0000-0002-1192-8707$$aAleta, A.$$uUniversidad de Zaragoza 000117688 245__ $$aA Need for a Paradigm Shift in Healthy Nutrition Research 000117688 260__ $$c2022 000117688 5060_ $$aAccess copy available to the general public$$fUnrestricted 000117688 5203_ $$aResearch in the field of sustainable and healthy nutrition is calling for the application of the latest advances in seemingly unrelated domains such as complex systems and network sciences on the one hand and big data and artificial intelligence on the other. This is because the confluence of these fields, whose methodologies have experienced explosive growth in the last few years, promises to solve some of the more challenging problems in sustainable and healthy nutrition, i.e., integrating food and behavioral-based dietary guidelines. Focusing here primarily on nutrition and health, we discuss what kind of methodological shift is needed to open current disciplinary borders to the methods, languages, and knowledge of the digital era and a system thinking approach. Specifically, we advocate for the adoption of interdisciplinary, complex-systems-based research to tackle the huge challenge of dealing with an evolving interdependent system in which there are multiple scales—from the metabolome to the population level—, heterogeneous and—more often than not— incomplete data, and population changes subject to many behavioral and environmental pressures. To illustrate the importance of this methodological innovation we focus on the consumption aspects of nutrition rather than production, but we recognize the importance of system-wide studies that involve both these components of nutrition. We round off the paper by outlining some specific research directions that would make it possible to find new correlations and, possibly, causal relationships across scales and to answer pressing questions in the area of sustainable and healthy nutrition. Copyright © 2022 Aleta, Brighenti, Jolliet, Meijaard, Shamir, Moreno and Rasetti. 000117688 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es 000117688 590__ $$a5.0$$b2022 000117688 592__ $$a0.875$$b2022 000117688 591__ $$aNUTRITION & DIETETICS$$b28 / 87 = 0.322$$c2022$$dQ2$$eT1 000117688 593__ $$aFood Science$$c2022$$dQ1 000117688 593__ $$aNutrition and Dietetics$$c2022$$dQ2 000117688 593__ $$aEndocrinology, Diabetes and Metabolism$$c2022$$dQ2 000117688 594__ $$a3.5$$b2022 000117688 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000117688 700__ $$aBrighenti, F. 000117688 700__ $$aJolliet, O. 000117688 700__ $$aMeijaard, E. 000117688 700__ $$aShamir, R. 000117688 700__ $$0(orcid)0000-0002-0895-1893$$aMoreno Vega, Y.$$uUniversidad de Zaragoza 000117688 700__ $$aRasetti, M. 000117688 7102_ $$12004$$2405$$aUniversidad de Zaragoza$$bDpto. Física Teórica$$cÁrea Física Teórica 000117688 773__ $$g9 (2022), 881465 [9 pp.]$$pFront. Nutr.$$tFrontiers in Nutrition$$x2296-861X 000117688 8564_ $$s4375314$$uhttps://zaguan.unizar.es/record/117688/files/texto_completo.pdf$$yVersión publicada 000117688 8564_ $$s2420349$$uhttps://zaguan.unizar.es/record/117688/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000117688 909CO $$ooai:zaguan.unizar.es:117688$$particulos$$pdriver 000117688 951__ $$a2025-11-13-15:00:40 000117688 980__ $$aARTICLE